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Brugada phenocopy is considered when a Brugada-type ECG pattern is present but with a low likelihood of true Brugada syndrome, as indicated by negative family history, genetic testing, or provocative testing with drugs, or ECG normalization after the removal of precipitants. Brugada phenocopy has been reported due to various causes such as fever and electrolyte imbalance. We describe a 22-year-old man who presented with aluminum phosphide poisoning, resulting in severe metabolic acidosis, myocarditis, and profound myocardial depression. He developed transient Brugada-like ECG changes and multiorgan dysfunction, requiring intensive management, including mechanical ventilation and inotropes. Brugada phenocopy is a rare manifestation of aluminum phosphide-associated toxic myocarditis. After a week of treatment, there was a significant improvement in cardiac function and overall clinical status.
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http://dx.doi.org/10.18502/jthc.v19i2.16207 | DOI Listing |
Cureus
August 2025
Acute Medicine, Norfolk and Norwich University Hospital, Norwich, GBR.
We report a case of a 50-year-old male with a history of Hodgkin lymphoma in the neck region (in remission), ischaemic heart disease, and hypothyroidism who presented with right-sided pleuritic chest pain, cough, fever and night sweats. Imaging revealed a large right-sided loculated pleural effusion. Electrocardiogram (ECG) demonstrated a spontaneous Type 1 Brugada pattern, absent in prior recordings.
View Article and Find Full Text PDFBrugada phenocopy (BrP) is an electrocardiographic (ECG) alteration that mimics Brugada syndrome (BrS) but lacks the associated genetic predisposition. It manifests as a transient pattern induced by reversible factors such as electrolyte imbalances, internal environment disturbances, and the use of certain drugs. In critically ill patients, hyperkalemia and acidosis are common triggers of this phenomenon, affecting ventricular repolarization and generating an ECG pattern identical to BrS.
View Article and Find Full Text PDFJ Electrocardiol
August 2025
Universidade Nove de Julho (UNINOVE), Campus Mauá, Mauá, SP, Brazil; Hcor, São Paulo, Brazil.
Propafenone is a class IC anti-arrhythmic drug used for the rhythm control strategy in atrial fibrillation worldwide, including in Latin America countries. Propafenone intoxication is a potentially life-threatening condition. Ventricular tachycardia and the Brugada electrocardiographic (ECG) pattern are possible pro-arrhythmic manifestations of propafenone poisoning.
View Article and Find Full Text PDFOxf Med Case Reports
May 2025
St. Joseph's University Medical Center, Department of Cardiology, Paterson, NJ 07470, United States.
Brugada Syndrome is a potentially fatal, hereditary cardiac disorder that may precipitate sudden cardiac death if not identified. An electrocardiogram (ECG) revealing a characteristic coved ST segment elevation followed by negative T wave in a right-sided precordial lead is pathognomonic for the Brugada pattern. Recently it has been shown that certain abnormalities, such as an electrolyte disturbance, may precipitate a Brugada pattern on ECG.
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