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Purpose: Athletes with hand function impairment are eligible to compete in handcycling using assistive technology designed to compensate for their reduced grip strength. However, there is no evidence suggesting that these athletes perform similarly to their peers without such impairments. This study examined the impact of three simulated hand function impairments on handcycling performance in non-disabled novices.
Materials And Methods: Fourteen non-disabled individuals voluntarily participated in four measurement sessions using a standard handbike. Different hand function levels were simulated in the four sessions (no impairment and three simulated conditions: asymmetry, finger, and wrist impairments) using strapping and gloves to enable cyclic motion. Each session included two 4-minute submaximal handcycling tests (at 30 W and 45 W) and one 20-second isokinetic sprint. Repeated measures ANOVA was used to analyze differences among the hand function conditions in oxygen uptake (VOsub) during submaximal tests and peak and mean power output (PO (W)) during the sprints.
Results: No significant differences in VOsub were observed across the four conditions. During the sprint, participants achieved higher peak PO without impairments compared to the simulated impairments, with values 14-17% higher ( < 0.01). However, no significant differences were found in mean PO, which was 5-9% higher without impairments but did not reach statistical significance ( ≥ 0.05).
Conclusion: The results suggest that individuals without hand function impairments may have an advantage over their peers with impairments during maximal efforts but not during submaximal efforts. However, these findings need to be validated in handcycling athletes.
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http://dx.doi.org/10.1080/17483107.2025.2492369 | DOI Listing |
Research (Wash D C)
September 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a high propensity for metastasis, poor prognosis, and limited treatment options. Research has demonstrated a substantial correlation between the expression of protein arginine N-methyltransferase 1 (PRMT1) and enhanced proliferation, metastasis, and poor outcomes in TNBC. However, the specific role of PRMT1 in lung metastasis and chemoresistance remains unclear.
View Article and Find Full Text PDFFront Artif Intell
August 2025
School of Computation and Communication Science and Engineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Computer vision has been identified as one of the solutions to bridge communication barriers between speech-impaired populations and those without impairment as most people are unaware of the sign language used by speech-impaired individuals. Numerous studies have been conducted to address this challenge. However, recognizing word signs, which are usually dynamic and involve more than one frame per sign, remains a challenge.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, the incidence of which continues to rise globally, and existing therapeutic options are limited by low drug bioavailability and systemic side effects. In this study, we systematically investigated the challenges of the special gastrointestinal environment of UC patients for oral drug delivery, such as extreme pH, degradation by digestive enzymes, metabolism of intestinal flora and obstruction of the intestinal mucosal barrier, and summarized the potential of plant-derived Exosome-like Nanovesicles (PELNs) as a novel delivery system. PELNs are produced by plant cells and mainly consist of proteins, RNA, lipids and plant active molecules.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
September 2025
Departamento de Física Aplicada - Instituto de Ciencia de Materiales, Matter at High Pressure (MALTA) Consolider Team, Universidad de Valencia, Edificio de Investigación, C/Dr Moliner 50, 46100 Burjassot, Valencia Spain.
The effects of pressure on the crystal structure of scheelite-type perrhenates were studied using synchrotron powder X-ray diffraction and density-functional theory. At ambient conditions, the studied materials AgReO, KReO, and RbReO, exhibit a tetragonal scheelite-type crystal structure described by space group 4/. Under compression, a transition from scheelite-to-M'-fergusonite (space group 2/) was observed at 1.
View Article and Find Full Text PDFCase Reports Plast Surg Hand Surg
September 2025
Plastic Surgery Unit, University Hospital Trust of Sassari, Sassari, Italy.
Reconstruction of the calcaneal region presents unique challenges due to its complex anatomy and critical weight-bearing function. This retrospective study aims to report our experience in cases of calcaneal defects repaired with various free flap types, and to evaluate the long-term outcomes of the reconstructions. We retrospectively reviewed 25 patients who underwent microsurgical free flap reconstruction for calcaneal defects between January 1997 and March 2022.
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