Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210054 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2025.04.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association Between Wnt Target Genes and Cortical Volumes in Alzheimer's Disease.
J Mol Neurosci
December 2023
Neurology Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan No. 1, Dongcheng District, Beijing, 100005, China.
The disproportionate cortical atrophy is an established biomarker for the pathophysiological process of Alzheimer's disease (AD). However, the genetic basis underlying the cortical atrophy remains poorly defined. Herein, we aim to illustrate the effect of the Wnt target genes on the cortical volumes of AD patients.
View Article and Find Full Text PDFAdolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.
Elife
October 2023
Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, Bethesda, United States.
Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive and novel paradigms investigating the circuit substrates underlying cognitive deficits are critically needed. The frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence.
View Article and Find Full Text PDFCo-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness.
Cells
July 2023
Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.
Background: Disrupted proteostasis is an emerging area of research into major depressive disorder. Several proteins have been implicated as forming aggregates specifically in the brains of subsets of patients with psychiatric illnesses. These proteins include CRMP1, DISC1, NPAS3 and TRIOBP-1.
View Article and Find Full Text PDFSmoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m modification.
Mol Ther
August 2023
Spine Labs, St. George & Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; Spine Service, Department of Orthopedic Surgery, St. George Hospital, Kogarah, NSW, Australia. Electronic address:
Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their correlations and the mechanisms of action remain unclear. We have shown that excessive activation of mast cells (MCs) and their proteases play key roles in CS-associated diseases, like asthma, chronic obstructive pulmonary disease (COPD), blood coagulation, and lung cancer. Previous studies have also shown that MCs and their proteases induce degenerative musculoskeletal disease.
View Article and Find Full Text PDF