Mutant macrophages CHIP in to help solid tumors.

Cell

Department of Pathology, Stanford University, Stanford, CA, USA; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA, USA. Electronic address:

Published: May 2025


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Article Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) promotes adverse outcomes in age-related diseases. However, the impact of CHIP on solid tumors has yet to be elucidated in large-scale cancer-focused cohorts. In a recently published article in the New England Journal of Medicine, Pich et al. provide evidence for a tumor-promoting role of CHIP in solid malignancies.

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http://dx.doi.org/10.1016/j.cell.2025.03.049DOI Listing

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