Article Synopsis
- The nervous system influences the immune system’s responses and development, particularly focusing on how the brain affects the growth of meningeal mural lymphatic endothelial cells (muLECs).
- Researchers found that a specific type of glial cell, called slc6a11b+ radial astrocytes (RAs), play a crucial role in developing muLECs through the secretion of vascular endothelial growth factor C (vegfc), which is regulated by neural activity in zebrafish.
- Additionally, these RAs work with another type of cell, ccbe1+ fibroblasts, to control and limit the growth of muLECs on the brain’s surface by managing how Vegfc is distributed, showing the complexity of cellular interactions in brain development
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Article Abstract
The nervous system regulates peripheral immune responses under physiological and pathological conditions, but the brain's impact on immune system development remains unknown. Meningeal mural lymphatic endothelial cells (muLECs), embedded in the leptomeninges, form an immune niche surrounding the brain that contributes to brain immunosurveillance. Here, we report that the brain controls the development of muLECs via a specialized glial subpopulation, slc6a11b+ radial astrocytes (RAs), a process modulated by neural activity in zebrafish. slc6a11b+ RAs, with processes extending to the meninges, govern muLEC formation by expressing vascular endothelial growth factor C (vegfc). Moreover, neural activity regulates muLEC development, and this regulation requires Vegfc in slc6a11b+ RAs. Intriguingly, slc6a11b+ RAs cooperate with calcium-binding EGF domain 1 (ccbe1)+ fibroblasts to restrict muLEC growth on the brain surface via controlling mature Vegfc distribution. Thus, our study uncovers a glia-mediated and neural-activity-regulated control of brain lymphatic development and highlights the importance of inter-tissue cellular cooperation in development.
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| http://dx.doi.org/10.1016/j.cell.2025.04.008 | DOI Listing |
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Neural-activity-regulated and glia-mediated control of brain lymphatic development.
Cell
June 2025
Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; School o
Article Synopsis
- The nervous system influences the immune system’s responses and development, particularly focusing on how the brain affects the growth of meningeal mural lymphatic endothelial cells (muLECs).
- Researchers found that a specific type of glial cell, called slc6a11b+ radial astrocytes (RAs), play a crucial role in developing muLECs through the secretion of vascular endothelial growth factor C (vegfc), which is regulated by neural activity in zebrafish.
- Additionally, these RAs work with another type of cell, ccbe1+ fibroblasts, to control and limit the growth of muLECs on the brain’s surface by managing how Vegfc is distributed, showing the complexity of cellular interactions in brain development