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Background And Study Aims: Completeness of esophagagogastroduodenoscopy (EGD) varies among endoscopists, leading to a high miss rate for gastric neoplasms. This study aimed to determine the effect of the Cerebro real-time artificial intelligence (AI) system on completeness of EGD for endoscopists in early stages of training.
Patients And Methods: The AI system was built with CNN and Motion Adaptive Temporal Feature Aggregation (MA-TFA). A prospective sequential cohort study was conducted. Endoscopists were taught about the standardized EGD protocol to examine 27 sites. Then, each subject performed diagnostic EGDs per protocol (control arm). After completion of the required sample size, subjects performed diagnostic EGDs with assistance of the AI (study arm). The primary outcome was the rate of completeness of EGD. Secondary outcomes included overall inspection time, individual site inspection time, completeness of photodocumentation, and rate of positive pathologies.
Results: A total of 466 EGDs were performed with 233 in each group. Use of AI significantly improved completeness of EGD [mean (SD) (92.6% (6.2%) vs 71.2% (16.8%)]; <0.001 (95% confidence interval 19.2%-23.8%, SD 0.012). There was no difference in overall mean (SD) inspection time [765.5 (338.4) seconds vs 740.4 (266.2); =0.374]. Mean (SD) number of photos for photo-documentation significantly increased in the AI group [26.9 (0.4) vs 10.3 (4.4); <0.001]. There was no difference in detection rates for pathologies in the two groups [8/233 (3.43%) vs 5/233 (2.16%), =0.399].
Conclusions: Completeness of EGD examination and photodocumentation by endoscopists in early stages of are improved by the AI-assisted software Cerebro.
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http://dx.doi.org/10.1055/a-2547-6645 | DOI Listing |
Fam Cancer
September 2025
Ambry Genetics, 1 Enterprise, Aliso Viejo, CA, 92656, USA.
Pathogenic variants in the APC gene are classically associated with autosomal dominant familial adenomatous polyposis (FAP), characterized by tens-to-thousands of colonic adenomatous polyps and a high-penetrance predisposition to colorectal cancer. More recently, specific PVs in the YY1 binding motif of APC promoter 1B have been associated with autosomal dominant gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS), characterized by tens-to-thousands of fundic gland polyps and a predisposition to gastric cancer but which are only rarely associated with features consistent with FAP. Although management guidelines currently treat FAP and GAPPS as mutually exclusive conditions, the extent of phenotypic overlap is not well-characterized.
View Article and Find Full Text PDFEndosc Int Open
July 2025
Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands.
Background And Study Aims: Active surveillance has been proposed for patients with esophageal cancer and a clinical complete response after neoadjuvant chemoradiotherapy (nCRT). This strategy involves repeated esophagogastroduodenoscopy (EGD) with bite-on-bite biopsies and endoscopic ultrasonography (EUS) with fine-needle aspiration (FNA) to detect tumor regrowth or residual disease. The aim of this study was to assess safety of endoscopic procedures during active surveillance.
View Article and Find Full Text PDFEndoscopy
August 2025
Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark.
The quality of esophagogastroduodenoscopy (EGD) performed by trainees depends on their competency level and training. This study assessed whether the addition of simulation-based training (SBT) reduces the number of supervised clinical procedures needed to achieve independent procedural completion compared with conventional clinically based training (CBT) alone.EGD novices were randomized (1 : 1) to either SBT followed by CBT or CBT alone in a randomized controlled trial.
View Article and Find Full Text PDFObjectives: Esophagogastroduodenoscopy (EGD) is widely used for gastric cancer (GC) screening in Japan; however, sedation during EGD is not recommended. We aimed to assess the tolerability of unsedated EGD (USEGD) in the Japanese population.
Methods: Participants who underwent GC screening in Japanese urban areas between July 2021 and December 2022 were included in this study.
Case Reports Hepatol
July 2025
Department of Medicine, Emory University Hospital, Atlanta, Georgia, USA.
A 43-year-old man presents to the hospital with two weeks of persistent fevers, accompanied by myalgias, hematochezia, and abdominal pain. Acute infectious causes were ruled out, and elevated inflammatory markers suggested inflammatory diarrhea or autoimmune conditions. Esophagogastroduodenoscopy (EGD) and colonoscopy were negative.
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