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http://dx.doi.org/10.1158/1078-0432.CCR-25-0070 | DOI Listing |
JMIR Res Protoc
September 2025
Service of Clinical Pharmacology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Background: Janus kinase inhibitors (JAKIs) are small molecules used orally to treat inflammatory and hematological disorders. They have demonstrated impressive efficacy across multiple indications. However, concerns have emerged regarding their safety profile.
View Article and Find Full Text PDFJ Environ Manage
September 2025
Zhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy (IRA), Zhejiang Shuren University, Hangzhou, 310015, China. Electr
The widespread coexistence of chiral herbicides and heavy metals (HMs) in agricultural soils poses significant ecological risks to crop safety, yet their combined ecotoxicological effects are not well understood. This study systematically investigated the enantiomer-specific effects of napropamide (R/S-NAP) on plant HMs accumulation. Results showed that S-NAP application reduced plant biomass and HMs accumulation, while R-NAP exhibited distinct effects, increasing root biomass and HMs accumulation in roots.
View Article and Find Full Text PDFEpilepsy Behav
September 2025
Danone Research & Innovation, Uppsalalaan 12, 3584 CT Utrecht, the Netherlands. Electronic address:
Purpose: Ketogenic diet therapy (KDT) has been successfully used as an effective management option for drug resistant epilepsy (DRE) since the 1920 s. The ketogenic formulation studied here (KetoCal) is nutritionally complete, very high in fat, and low in carbohydrates and has played a crucial role in supporting the implementation of KDT for over twenty-five years. This scoping review aims to synthesise the existing literature regarding the safety, acceptability, and efficacy of the ketogenic formulation in supporting the management of DRE.
View Article and Find Full Text PDFJ Therm Biol
September 2025
Department of Integrative Biology, University of South Florida, St. Petersburg, FL, USA. Electronic address:
Urbanization and climate warming have contributed to global amphibian declines in recent decades, and amphibians are particularly vulnerable to warming because temperature influences their physiological processes across all life stages. Tadpole responses to warming in tropical climates are relatively understudied, and previous studies demonstrated species-specific responses to warming temperature. Warming ponds may quicken tadpole development and increase thermal tolerances, but increasing local temperatures push populations towards their physiological limits.
View Article and Find Full Text PDFNeurology
October 2025
Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies - EpiCARE, Rome, Italy.
Objectives: Neuronal ceroid lipofuscinosis type 3 (CLN3) is a rare lysosomal storage disorder characterized by progressive neurodegeneration. No disease-modifying treatments are currently available. Miglustat, a substrate reduction therapy, has shown preclinical efficacy in CLN3 models (conference abstract).
View Article and Find Full Text PDF