Anti-hypoxia polyacetylenes and sesquiterpenoids from (Franch.) Nannf.

A new polyacetylene, codonopsisylene (), has been extracted from the roots of , along with 14 previously reported compounds, including two polyacetylenes () and twelve sesquiterpenoids (). The chemical structures of these compounds were thoroughly characterised using a variety of spectroscopic techniques, combined with calculated NMR and ECD data. Anti-hypoxia activities of all isolated compounds were conducted using a CCK-8 assay. Among them, compounds and demonstrated anti-hypoxia effects by inhibiting ROS overexpression, reducing excessive LDH release and enhancing ΔΨm.