Effectiveness and Safety of Butyphthalide Injection in Treatment of Aphasia after Cerebral Infarction: A Meta-analysis.

Objective: The objective of this study is to evaluate the efficacy and safety of butylphthalide injection in the treatment of aphasia after cerebral infarction.

Methods: CNKI, Wanfang database, Duxiu, VIP, CBM, PubMed, Embase, Web of Science, Cochrane, and Socolar databases were searched from the establishment of the database to August 2024. According to the topic of butylphthalide injection treated aphasia after cerebral infarction, the eligible RCT was selected and meta-analysis was performed using RevMan 5.4 software and stata16 software. Two researchers independently screened the study, extracted the basic information in the study, and assessed the risk of bias in the study.

Results: A total of 1047 patients were included in 12 articles, including 524 patients in the experimental group (butylphthalide injection + conventional/special speech rehabilitation training) and 523 patients in the control group (conventional/special speech rehabilitation). The results of meta-analysis showed that the total clinical efficacy of the experimental group was better than that of the control group (RR=1.29, 95%CI: 1.17-1.43, Z=4.98, P < 0.0000). The National Institutes of Health Stroke Scale (NIHSS) score of the experimental group was lower than that of the control group (conventional language rehabilitation training group: MD=-4.11,95%CI: -4.44~- 3.78, Z=24.38, P < 0.00001; special language rehabilitation training group: MD=-2.53, 95%CI: - 3.77 ~ -1.28, Z=3.97, P < 0.00001). Aphasia Quotient (AQ) scores of experimental groups were higher than those of control group (conventional language rehabilitation training group: MD=11.10, 95%CI: 10.26 ~ 11.94, Z=25.97, P<0.00001; special language rehabilitation training group: MD=5.23, 95%CI: 3.34~7.11, Z=5.44, P<0.00001); Adverse reactions: P>0.05, no statistical significance.

Conclusion: Butylphthalide injection is effective and safe in the treatment of aphasia after cerebral infarction.