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Eosinophilic gastroenteritis is a rare gastrointestinal disease characterized by eosinophilic infiltration of the gastrointestinal mucosa, muscle layer, or serosal layer. Gastrointestinal symptoms, laboratory tests, imaging, and endoscopy can provide important diagnostic basis for eosinophilic gastroenteritis, but the final diagnosis needs to be confirmed via pathological biopsy. We herein report the case of a middle-aged woman with abdominal pain for 5 days, which was aggravated for 1 day. Gastroscopic pathology showed individual nondiffuse eosinophils (concentration of <10 eosinophils/high power field) in the fundus and antrum. Eosinophils with a maximum concentration of 80/high power field were uniformly distributed in the stroma and specific epithelium of the duodenal bulb. Eosinophils were infiltrated in the submucosa as well as the perivascular and vascular walls of the descending duodenum, with a maximum concentration of approximately 130/high power field. After 5 days of intravenous meprednisolone treatment, the symptoms improved and the patient was discharged healthy. After reviewing the literature, we recommend that if a patient exhibits gastrointestinal symptoms and elevated blood eosinophil levels with co-existing atopic diseases, such as asthma and allergic rhinitis, the clinician should perform gastroenteroscopy and pathological biopsy after ruling out tumor, tuberculosis, and infection.
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http://dx.doi.org/10.1177/03000605251332886 | DOI Listing |
Gastroenterol Hepatol (N Y)
August 2025
Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
For eosinophilic esophagitis (EoE), the most well researched of the eosinophilic gastrointestinal diseases (EGIDs), there is a plethora of knowledge for its diagnosis and management; however, much less guidance is available for the non-EoE EGIDs. Efforts have been made to characterize the clinical features, epidemiology, diagnosis, and natural history of EGIDs, as the frequency of the non-EoE EGIDs has continued to rise. The diagnosis of the different non-EoE EGIDs, eosinophilic gastritis, enteritis, and colitis, can be challenging because of their rarity and heterogeneous presentations which can lead to delayed diagnosis and poor health-related quality of life in affected patients.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, Palestine.
Background: Idiopathic hypereosinophilic syndrome (iHES) is a rare hematologic condition characterized by persistent, unexplained eosinophilia and organ involvement. Its diagnosis is challenging due to overlapping features with other eosinophilic and inflammatory gastrointestinal disorders.
Case Presentation: We report a case of a 44-year-old male with a history of asthma who presented with chronic epigastric pain, rectal bleeding, and significant weight loss.
J Surg Case Rep
August 2025
Gastroenterology and Hepatology Department, Saint Joseph's University Medical Center, 703 Main Street, Paterson, NJ 07503, United States.
Systemic mastocytosis (SM) is a rare myeloproliferative neoplasm characterized by the clonal proliferation of mast cells in various organs, including the gastrointestinal (GI) tract. GI manifestations of SM, often non-specific, can lead to misdiagnosis, with symptoms overlapping those of common disorders such as achalasia, eosinophilic gastroenteritis, and inflammatory bowel disease. This case report details the diagnosis and management of an 83-year-old female with progressive dysphagia and weight loss, initially suspected to have achalasia.
View Article and Find Full Text PDFCurr Gastroenterol Rep
August 2025
Department of Medical Gastroenterology, JIPMER, Puducherry, India.
Purpose Of Review: Eosinophilic colitis (EoC) has an increasing association with inflammatory bowel disease (IBD), and there is a paucity of data on the natural history of EoC. Here, we provide a comprehensive overview of EoC and critically evaluate the evidence supporting its potential association with, or evolution into IBD.
Recent Findings: Experts currently classify EoC as one of the eosinophilic gastrointestinal disorders (EGID) beyond eosinophilic esophagitis (EoE).
Dis Esophagus
July 2025
Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, 130 Mason Farm Rd, Chapel Hill, NC 27599, USA.
Telehealth remains understudied in patients with eosinophilic esophagitis and eosinophilic gastrointestinal diseases (EGIDs), yet may serve as an important tool for increasing access to providers with EGID-specific expertise. The online patient-centered research network, EGID Partners, provided insight into EGID-related telehealth utilization. Respondents reported that telehealth visits offered the ability to spend adequate time with their healthcare provider and communicate just as effectively as an in-person visit, while also incurring lower travel-related costs and less missed work or school.
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