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Grafting compatibility refers to the successful healing between stock and scion, as well as the normal functioning of their tissues. This article investigates the survival rates and growth conditions of various Sapindus grafting combinations and establishes a new evaluation system for Sapindus grafting compatibility. This system aims to provide theoretical support for predicting Sapindus grafting compatibility and enhancing the development of improved varieties. The study utilizes 15 Sapindus grafting combinations as research materials, assesses their survival rates and growth conditions, employs the CRITIC method to calculate weights, and develops a Sapindus grafting compatibility evaluation model. By analyzing the physiological characteristics of the scion leaves from these 15 grafting combinations, variance analysis, cluster analysis, and linear regression models were utilized to assess the accuracy of the grafting compatibility evaluation model. The results indicate that the growth of grafted plants serves as a critical evaluation index of grafting compatibility, providing a more scientific approach than relying solely on survival rate metrics. This research offers a theoretical foundation and data support for predicting Sapindus grafting compatibility; an effective prediction model will substantially enhance the efficiency of breeding and promoting improved varieties, thereby fostering the growth of the Sapindus industry.
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http://dx.doi.org/10.1038/s41598-025-92823-x | DOI Listing |
J Vis Exp
August 2025
Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University; Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Chinese Academy of Medical Sciences; Guangdong Provincial Key Laboratory of Large Animal Models for Biomedici
Xenogeneic cell transplantation often faces significant immune rejection, even in immunodeficient animal models. Among residual immune components, macrophages can actively phagocytose transplanted human cells, posing a challenge to long-term engraftment. To address this, we developed a standardized in vitro assay to quantify macrophage-mediated phagocytosis of human versus rat red blood cells (RBCs).
View Article and Find Full Text PDFAm J Hematol
September 2025
Université D'angers, Université de Nantes, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France.
Loss of function mutations in the gene encoding WASP (Wiskott-Aldrich syndrome protein) result in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia-XLT (WAS/XLT). The clinical severity of the disease can be assessed using the WAS clinical severity score. Typically, patients with a score of 3 or less at 2 years of age are considered to have mild WAS/XLT disease.
View Article and Find Full Text PDFTranspl Immunol
September 2025
Molecular and Transplant Immunology Laboratory, Department of Transfusion Medicine (Blood Center), Medanta-The Medicity, Gurgaon, Haryana, India.
Over 60 % of kidney transplant candidates are non-sensitised while remaining 40 % are sensitised because of previous exposure to human alloantigens during previous transplants, blood transfusions, and pregnancy in women. Pre-transplant compatibility testing is mandatory prior to renal transplantation for detecting the presence of donor-specific antibodies (DSAs), which are associated with early hyperacute/acute and later chronic rejections. Initially, complement-dependent cytotoxicity crossmatch (CDCXM) was used as a traditional method for detecting preformed DSAs.
View Article and Find Full Text PDFHum Immunol
September 2025
Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Heart transplant candidates that are highly sensitized against human leukocyte antigens (HLA) face ongoing challenge in finding immunologically compatible donors. Desensitization strategies aimed at reducing HLA antibody titers have variable success rates. Imlifidase, a novel immunoglobulin G-degrading enzyme derived from Streptococcus pyogenes has been successfully used to eliminate pre-formed antibodies in sensitized kidney transplant recipients.
View Article and Find Full Text PDFMol Cells
September 2025
Department of Neuroscience, Kyung Hee University, Seoul, South Korea; Department of Physiology, Kyung Hee University School of Medicine, Seoul, South Korea. Electronic address:
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded α-synuclein. Current treatments, including dopaminergic medications and deep brain stimulation (DBS), provide symptomatic relief but do not halt disease progression. Recent advances in molecular research have enabled the development of disease-modifying strategies targeting key pathogenic mechanisms, such as α-synuclein aggregation, mitochondrial dysfunction, and genetic mutations including LRRK2 and GBA1.
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