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Background: Boerhaave syndrome, or spontaneous esophageal rupture, is a rare and life-threatening emergency, typically caused by a sudden increase in esophageal pressure due to violent coughing or vomiting. Early diagnosis is challenging as its symptoms often resemble those of other diseases. Understanding its pathological features and treatment strategies is therefore critical for clinical practice.
Case Summary: This report describes a case of spontaneous esophageal rupture triggered by violent coughing in a 55-year-old male with a history of smoking and hypertension. Following severe coughing, the patient developed chest pain, vomiting, and respiratory distress. Initial clinical evaluation was inconclusive, with a suspected diagnosis of cardiovascular or gastrointestinal conditions. After further examination, the diagnosis of spontaneous esophageal rupture was confirmed. Chest X-ray, computed tomography, and endoscopy revealed a rupture in the lower esophagus, along with mediastinal abscess and pleural effusion. Laboratory tests showed mild infection markers. The patient underwent surgical repair of the esophageal rupture (approximately 3 cm in length) with mediastinal drainage. Postoperatively, the patient's temperature normalized within 3 days, respiratory function improved, and pleural effusion significantly decreased. After two weeks of treatment, the patient was discharged without complications and had a favorable prognosis. The study suggests that while violent coughing is a rare trigger, it can lead to severe damage, and imaging techniques play a crucial role in diagnosis.
Conclusion: Spontaneous esophageal rupture presents significant diagnostic and therapeutic challenges. Early recognition and timely intervention are crucial for improving prognosis. This case highlights the importance of imaging and surgical treatment, offering new insights for managing similar cases and providing valuable clinical guidance.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019034 | PMC |
http://dx.doi.org/10.4240/wjgs.v17.i4.101578 | DOI Listing |
Aortoesophageal fistula (AEF) is a rare but life-threatening condition. Initial management typically includes thoracic endovascular aortic repair (TEVAR) or aortic graft replacement to achieve hemostasis, followed by esophagectomy with aortic graft replacement and greater omentum wrapping to eliminate the source of infection. We report a case of successful endoscopic closure of a chronic esophageal fistula secondary to AEF.
View Article and Find Full Text PDFSurg Endosc
August 2025
Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Background: Esophageal perforation (EP) is a rare but life-threatening condition with an incidence of approximately 3.1 per million annually. While iatrogenic injury during endoscopy is the leading cause, other etiologies include spontaneous rupture, trauma, and malignancy.
View Article and Find Full Text PDFCureus
July 2025
Anesthesiology, West China Hospital, Sichuan University, Chengdu, CHN.
Boerhaave syndrome, a rare yet life-threatening spontaneous esophageal rupture, is classically associated with forceful emesis. We present a case of a 48-year-old male with no prior esophageal pathology who developed vomiting, epigastric pain and dyspnea after undergoing an elective colonoscopy. Notably, the patient had experienced emesis following alcohol consumption the day prior to the colonoscopy procedure but did not disclose this history during the pre-procedural assessment.
View Article and Find Full Text PDFEur J Pharmacol
August 2025
Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, China; Department of Physiology, Shanxi Medical University, Taiyuan, China. Electronic address:
Thoracic aortic aneurysm (TAA) is life-threatening once developing to dissection (TAAD) or rupture and currently there is no effective pharmacological treatment. The abnormal activity of inducible nitric oxide synthase (iNOS) has been related with syndromic TAA, but its potential role in non-syndromic TAA is unknown. Here we identified elevations of inducible nitric oxide synthase (iNOS) and its downstream protein kinase G1 (PRKG1) in both human non-syndromic TAA and β-aminopropionitrile (BAPN)-induced mouse model of TAA.
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