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Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade malignant tumor composed of clear cytoplasmic cells. It mainly arises from the minor salivary glands of the oral cavity and oropharynx of the head and neck region. As a relatively slow-growing tumor, the main symptom of HCCC is indolent discomfort associated with enlargement and little local pain. This report presents a 33-year-old female patient with HCCC at the base of the tongue and reviews 12 cases of HCCC occurring at the base of the tongue with a surgical procedure in detail. In most cases, excision was performed using the mandibulotomy or a transcervical approach. However, it was a small, low-grade malignant tumor in this case, and the transoral approach was adopted. This minimally invasive procedure allows early oral intake and a short hospitalization period. The oral method is also considered a useful surgical approach for treating HCCC of the base of the tongue.
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http://dx.doi.org/10.7759/cureus.81249 | DOI Listing |
Front Immunol
September 2025
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Introduction: Cutaneous manifestations in adult-onset immunodeficiency (AOID) resulting from anti-interferon-gamma autoantibody (AIGA) are prevalent and can be classified into infective and reactive disorders. To date, no clinical studies have specifically examined pustular reaction in patients with AOID. This study aimed to provide an original characterization of the clinical manifestations associated with pustular reaction in AOID and to compare these features with those observed in a clinically similar entity, generalized pustular psoriasis (GPP).
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Medicine, Islamic International Medical College, Rawalpindi, Pakistan.
J Robot Surg
September 2025
Ayub Medical College Abbottabad, Abbottabad, Pakistan.
J Robot Surg
September 2025
Ayub Medical College, Abbottabad, Pakistan.
Dis Model Mech
September 2025
Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
The necessity of reliable preclinical models for evaluating the efficacy of novel therapeutic strategies is imperative. Nevertheless, the degree to which tumor-bearing murine models represent the immunological characteristics of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has largely been unexplored. Utilizing single-cell RNA sequencing technology, our research elucidated that subcutaneous (SC) murine models more accurately reflect the early immunogenic phase of human HPV-positive OPSCC, marked by a stage-dependent increase in effector T cell infiltration.
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