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Aims: A soft-tissue sparing posterior surgical approach (SPAIRE) for hip hemiarthroplasty after femoral neck fractures is hypothesized to provide better functional results than the standard direct lateral approach, while maintaining a low dislocation rate. The aim of this study was to compare rate of complications and functional results between these approaches in a clinical cohort.
Methods: Prospectively collected registry data on all femoral neck fracture cases treated with hemiarthroplasty between September 2018 and November 2022 in a single Norwegian hospital were analyzed grouped by SPAIRE versus direct lateral approach. Outcomes were prosthesis dislocation, surgical site infection, 30-day mortality, and tests of function three months postoperatively. Linear regression was used for continuous outcomes, and dichotomous outcomes were analyzed by logistic regression and contingency tables.
Results: Of 858 cases, 430 were operated using SPAIRE, and 428 using direct lateral approach. There were no group differences in prosthesis dislocation rate (SPAIRE 0.7 % vs direct lateral 0.9 %, p = 0.725), and no differences in surgical site infections or 30-day mortality. In the patients with three months follow-up (total n = 372; SPAIRE n = 192; direct lateral n = 180) the SPAIRE group had better functional outcomes; New Mobility Score: 6.1 vs 5.0 (difference 1.1, p < 0.001), New Mobility Score change from preoperative: -1.3 vs -1.8 (difference 0.5, p = 0.024), Short Physical Performance Battery: 7.3 vs. 5.9 (difference 1.4, p < 0.001), Walking speed: 0.8 vs 0.7 m/s (difference 0.1, p < 0.001).
Conclusion: We found no differences in the rate of prosthesis dislocations, infections, or mortality between the SPAIRE and the direct lateral approach. Functional outcomes were better in patients operated with the SPAIRE approach.
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http://dx.doi.org/10.1016/j.injury.2025.112339 | DOI Listing |
Methods Cell Biol
September 2025
The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, P.R. China; Medical and Health Research Institute, Zhengzhou Research Institute of HIT, Zhengzhou, HA, P.R. China. Electronic address:
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle weakness, paralysis, and death. While there is a plethora of studies focusing on many aspects of ALS, the pathogenesis of this disease is not well understood, and effective treatments are scarce. Drosophila melanogaster is a powerful model organism for studying ALS due to its genetic tractability and its evolutionarily conserved cellular and molecular processes which are also shared between the fly and human.
View Article and Find Full Text PDFPhys Med
September 2025
Department of Biomedical Technology, Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 8, 33720 Tampere, Finland; School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, Jan Smutslaan 1, 2050 Braamfontein, South Africa.
Background And Objective: Correction of rotational setup errors by tilting the treatment couch improves target dose accuracy and prevents healthy tissue overdosage in external beam radiotherapy. However, couch tilts may cause secondary patient motion. This study aimed to quantify the secondary motion caused by pitch and roll corrections and to evaluate the feasibility of surface imaging for detecting the secondary motion in pelvic radiotherapy.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Institute for Medical Laboratory Diagnostics, Helios University Hospital, Witten/Herdecke University, Wuppertal, Germany.
Carbapenem-resistant organisms (CRO) have rapidly spread worldwide in recent years, posing a significant challenge to both human health and healthcare systems. Timely and accurate detection of CRO, especially carbapenemase-producing and non-fermenters, is crucial for clinical prevention and treatment of these infections. In the present study, we subjected more than 114 multidrug-resistant Gram-negative and non-fermenters to two tests for the timely detection of carbapenemases.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Parkinson's disease (PD) often presents with lateralized motor symptoms at onset, reflecting asymmetric degeneration of the substantia nigra (SN). Neuromelanin (NM) loss and iron accumulation are hallmarks of SN pathology in PD, but their spatial distribution and interrelationship in PD patients with right-sided (PDR) or left-sided (PDL) motor symptom onset remain unclear.
Purpose: To investigate the spatial vulnerability and interrelationship of NM and iron in the SN among PDR, PDL, and healthy controls (HCs) using MRI.
iScience
September 2025
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Goal-directed behavior requires adjusting cognitive control, both in preparation for and in reaction to conflict. Theta oscillations and population activity in dorsomedial prefrontal cortex (dmPFC) and dorsolateral PFC (dlPFC) are known to support reactive control. Here, we investigated their role in proactive control using human intracranial electroencephalogram (EEG) recordings during a Stroop task that manipulated conflict expectations.
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