A novel technique for the quality assurance of dwell positions for ovoid applicators using 2D optical imaging.

Brachytherapy

Princess Margaret Cancer Center, Toronto, Ontario, Canada; University of Toronto, Department Radiation Oncology, Toronto, Ontario, Canada; University of Toronto, Department Medical Biophysics, Toronto, Ontario, Canada; University of Toronto, Institute of Biomedical Engineering, Toronto, Ontario, Can

Published: August 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Purpose: We propose a new method for commissioning lunar ovoid applicators in high dose rate gynecology brachytherapy based on 2D optical scintillating imaging of the applicators.

Methods: Treatment plans were generated for 22 mm and 26 mm diameter Venezia applicators, using four to eight dwell positions in each ovoid. Images of the applicator dwell positions were acquired using a pinhole apparatus combined with scintillating material and optical camera. Images were acquired for individual dwell positions and processed to identify pixel locations with peak signal intensity. Catheter dwell positions were used to register pixel locations in the optical images and absolute coordinates of the applicator in the treatment planning system. Errors were calculated using the standard deviation in the Euclidean distance between measured and expected ovoid dwell positions. Measurements were repeated three times, including repositioning the applicator on the measurement system.

Results: Imaging of each applicator required between 20 and 25 min for all dwell positions. Catheter registration errors were 0.14 ± 0.09 mm and 0.21 ± 0.04 mm for the 26 and 22 mm applicators, respectively. Average differences between the imaged and planned ovoid dwell positions were 0.48 ± 0.14 mm and 0.48 ± 0.16 mm for the 26 and 22 mm applicators, respectively. The maximum difference between the measured and planned ovoid positions was 0.7 mm and 1.3 mm measured for the 26 and 22 mm applicators, respectively. These uncertainties are lower than our clinical tolerance of 2.0 mm.

Conclusions: 2D-Scintillating imaging of lunar ovoid applicator dwell positions is feasible, accurate and faster than previous methods used at our center.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brachy.2025.03.003DOI Listing

Publication Analysis

Top Keywords

dwell positions
36
positions
10
dwell
9
positions ovoid
8
ovoid applicators
8
lunar ovoid
8
applicator dwell
8
pixel locations
8
ovoid dwell
8
planned ovoid
8

Similar Publications

Introduction: Midline catheters (MCs) longer than 15 cm are increasingly used for intravenous therapy. However, a consensus on the safe administration of irritating infusates (pH <5 or >9, osmolality >900 mOsm/L) is lacking. The current guidelines do not specify how the catheter tip position (axillary vein of the chest wall or subclavian vein) modulates the complication risks.

View Article and Find Full Text PDF

Actin monomers influence the interaction between cyclase-associated protein 1 and actin filaments.

bioRxiv

August 2025

Division of Nano Life Science, Graduate School of Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.

Cyclase-associated protein (CAP) binds to both actin monomers and filaments and regulates multiple aspects of the actin dynamics including polymerization and depolymerization. CAP has been isolated from multiple species as a stable equimolar complex with actin monomer. However, functional significance of the CAP-actin complex is unknown.

View Article and Find Full Text PDF

Development and computer-assisted validation of a radio frequency identification system for tracking individual chicken visits to functional areas.

Poult Sci

July 2025

Animal Health and Animal Welfare, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6b, 18059 Rostock, Germany; Chair of Animal Welfare, Ethology, Animal Hygiene and Animal Husbandry, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LM

Understanding how laying hens interact with functional resources-such as drinkers, feeders, perches, nest boxes, and wintergardens-is essential for meeting their physiological needs and enabling species-specific behaviors. This knowledge is crucial for poultry welfare assessments and precision livestock management. However, traditional ethological data collection methods, including direct observation and manual video analysis, are labor-intensive, prone to observer bias, and impractical for individual-level tracking.

View Article and Find Full Text PDF

Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity.

Biol Res

July 2025

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, 4070043, Chile.

Background: Maintenance of nucleosome-free regions at gene regulatory regions conform a relevant aspect within chromatin dynamics. In the yeast Saccharomyces cerevisiae, Reb1 and Abf1 are among the transcriptions factors that perform this molecular function. These factors are thought to act as a barrier to nucleosome sliding that chromatin remodeling complexes such as ISW1a perform towards this region, being binding affinity a critical feature to act as a barrier.

View Article and Find Full Text PDF

The aim of this research is to determine the effects of the variations in the implant angulation and the selection of abutment type on the mechanical potential of prosthetic components and to compare the deformations of abutment screws through micro-CT analysis. Forty titanium implants, each measuring 4.1 mm in diameter and 12 mm in length, were positioned in acrylic resin models in both straight and angled positions.

View Article and Find Full Text PDF