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Purpose: We propose a new method for commissioning lunar ovoid applicators in high dose rate gynecology brachytherapy based on 2D optical scintillating imaging of the applicators.
Methods: Treatment plans were generated for 22 mm and 26 mm diameter Venezia applicators, using four to eight dwell positions in each ovoid. Images of the applicator dwell positions were acquired using a pinhole apparatus combined with scintillating material and optical camera. Images were acquired for individual dwell positions and processed to identify pixel locations with peak signal intensity. Catheter dwell positions were used to register pixel locations in the optical images and absolute coordinates of the applicator in the treatment planning system. Errors were calculated using the standard deviation in the Euclidean distance between measured and expected ovoid dwell positions. Measurements were repeated three times, including repositioning the applicator on the measurement system.
Results: Imaging of each applicator required between 20 and 25 min for all dwell positions. Catheter registration errors were 0.14 ± 0.09 mm and 0.21 ± 0.04 mm for the 26 and 22 mm applicators, respectively. Average differences between the imaged and planned ovoid dwell positions were 0.48 ± 0.14 mm and 0.48 ± 0.16 mm for the 26 and 22 mm applicators, respectively. The maximum difference between the measured and planned ovoid positions was 0.7 mm and 1.3 mm measured for the 26 and 22 mm applicators, respectively. These uncertainties are lower than our clinical tolerance of 2.0 mm.
Conclusions: 2D-Scintillating imaging of lunar ovoid applicator dwell positions is feasible, accurate and faster than previous methods used at our center.
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http://dx.doi.org/10.1016/j.brachy.2025.03.003 | DOI Listing |
BMJ Open
August 2025
Department of Nursing, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China
Introduction: Midline catheters (MCs) longer than 15 cm are increasingly used for intravenous therapy. However, a consensus on the safe administration of irritating infusates (pH <5 or >9, osmolality >900 mOsm/L) is lacking. The current guidelines do not specify how the catheter tip position (axillary vein of the chest wall or subclavian vein) modulates the complication risks.
View Article and Find Full Text PDFbioRxiv
August 2025
Division of Nano Life Science, Graduate School of Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Cyclase-associated protein (CAP) binds to both actin monomers and filaments and regulates multiple aspects of the actin dynamics including polymerization and depolymerization. CAP has been isolated from multiple species as a stable equimolar complex with actin monomer. However, functional significance of the CAP-actin complex is unknown.
View Article and Find Full Text PDFPoult Sci
July 2025
Animal Health and Animal Welfare, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6b, 18059 Rostock, Germany; Chair of Animal Welfare, Ethology, Animal Hygiene and Animal Husbandry, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LM
Understanding how laying hens interact with functional resources-such as drinkers, feeders, perches, nest boxes, and wintergardens-is essential for meeting their physiological needs and enabling species-specific behaviors. This knowledge is crucial for poultry welfare assessments and precision livestock management. However, traditional ethological data collection methods, including direct observation and manual video analysis, are labor-intensive, prone to observer bias, and impractical for individual-level tracking.
View Article and Find Full Text PDFBiol Res
July 2025
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, 4070043, Chile.
Background: Maintenance of nucleosome-free regions at gene regulatory regions conform a relevant aspect within chromatin dynamics. In the yeast Saccharomyces cerevisiae, Reb1 and Abf1 are among the transcriptions factors that perform this molecular function. These factors are thought to act as a barrier to nucleosome sliding that chromatin remodeling complexes such as ISW1a perform towards this region, being binding affinity a critical feature to act as a barrier.
View Article and Find Full Text PDFInt J Dent
June 2025
Department of Prosthodontics, Faculty of Dentistry, Istanbul Medipol University, Istanbul, Türkiye.
The aim of this research is to determine the effects of the variations in the implant angulation and the selection of abutment type on the mechanical potential of prosthetic components and to compare the deformations of abutment screws through micro-CT analysis. Forty titanium implants, each measuring 4.1 mm in diameter and 12 mm in length, were positioned in acrylic resin models in both straight and angled positions.
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