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Article Abstract

Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents the construction of durable nanoshells composed of an Fe-phytic acid metal-organic complex around individual probiotic cells, providing exceptional cytoprotective properties, in single-cell nanoencapsulation. Nanoencapsulated maintains high viability under simulated gastric fluid and the antibiotic tetracycline. The Fe-phytic acid nanoshells provide an effective platform for improving the viability and functionality of probiotics in therapeutic and nutritional applications.

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http://dx.doi.org/10.1021/acs.langmuir.5c00722DOI Listing

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