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Background And Objectives: The effects of child maltreatment victimization affect the life-course trajectories of families including increasing risk of engaging in elder mistreatment when assuming a family caregiving role. This study evaluates the social-emotional information process theory as a mechanism that causally connects child maltreatment victimization with later engagement in elder mistreatment in the context of dementia family caregiving.
Research Design And Methods: During a 12-month observational longitudinal study, self-identified family caregivers to persons with dementia (N = 457) were recruited nationally to complete online surveys at enrollment, and 6- and 12-month follow-up. Through a multilevel serial mediation model, we tested the hypothesis that the causal role of past child maltreatment victimization on present-day engagement in elder mistreatment is mediated by cognitive processes (i.e., hostile attribution biases about the care recipient's behaviors) and emotional processes (i.e., caregivers' emotion regulation abilities).
Results: Findings show that child maltreatment has a significant indirect effect on elder mistreatment through hostile attribution bias and emotion dysregulation, and that these mediators fully account for the relationship between child maltreatment history and present-day use of elder mistreatment. The total effect of the mediation model is significant (b = 0.016, SD = 0.004, CI [0.010-0.024], p < .001), and the total variance explained in present-day elder mistreatment is 36%.
Discussion And Implications: A major contribution is the demonstration of modifiable mechanisms for the intergenerational transmission of violence as applied to elder mistreatment. Findings highlight the importance of a life-course view and the consideration of early-life experiences on behavioral aging outcomes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129107 | PMC |
http://dx.doi.org/10.1093/geront/gnaf132 | DOI Listing |
Nat Commun
September 2025
Department of Biochemistry, University of Illinois, Urbana-Champaign, IL, USA.
Individuals with progressive liver failure risk dying without liver transplantation. However, our understanding of why regenerative responses are disrupted in failing livers is limited. Here, we perform multiomic profiling of healthy and diseased human livers using bulk and single-nucleus RNA- and ATAC-seq.
View Article and Find Full Text PDFJ Am Acad Psychiatry Law
September 2025
Dr. Dernbach is a medical toxicologist and current addiction psychiatry fellow, Department of Psychiatry, Harvard Medical School, Boston, MA. Dr. Appel is a Professor of Psychiatry and Medical Education, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Clinicians face the prospect of mandated reporting when a patient reports, either during the intake appointment or during the course of addiction treatment, their risky substance use-related behavior around a child. Beyond legal considerations, many factors might influence a clinician's decision whether or not to report the case to child protective services (CPS). Although there is literature regarding mandated reporting in the setting of pre- or perinatal substance use, there is limited literature regarding the mandated reporting obligation in the setting of postnatal substance use around children.
View Article and Find Full Text PDFBiol Psychiatry
September 2025
Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, CA; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Canada; Division of Endocrinology, Children's Hospital LA, Los Angeles, CA; Department of Pediatrics, Keck Scho
Background: Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigations into biological processes that have been perturbed by ELA have profiled DNA methylation in whole blood and coalesced around perturbations of immunobiology being centrally insulted by ELA.
Methods: To identify novel molecular signatures that are enduringly perturbed by childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques that had either experienced nurturing maternal care (CONT, n = 7, 4M 3F) or maltreatment in infancy (MALT, n = 6, 3M 3F).
Child Prot Pract
April 2025
Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Introduction: In the U.S., child abuse and neglect (CAN) is a significant public health problem.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Background: Previous studies indicate that hippocampal (subfield) and amygdala volumes may correlate with specific cognitive functions, coping strategies and emotion regulation. Here, we investigated associations between emotional processing and volumes of hippocampal subfields and amygdala. We focused on depressed patients since emotional dysregulation and hippocampal volume shrinkage are characteristic of them.
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