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Posterior pillar augmentation palatoplasty added to the secondary intravelar velolplasty (PPAP + Re:IVVP) is a modification of re-repair technique intended to lengthen the palate. The current study aims to report the technical details of the modified procedure, its outcome and suggest its indication within the velopharyngeal incompetence (VPI) management protocol. A prospective cohort study examined a consecutive patient series who underwent PPAP + Re:IVVP for VPI during the period from 2015 to 2021. Speech outcome using the Cleft Audit Protocol for Speech (CAPS) score, complications and predictive factors for outcome were reported. Fifty-five cases had PPAP + Re:IVVP procedure with a mean age at the procedure of 87.6 months (range 27-256). The primary diagnoses were unilateral cleft lip and palate in 25 cases (44.5 %), bilateral cleft lip and palate in 12 cases (21.8 %), isolated cleft palate in 15 cases (27.2 %) and submucous cleft palate in 3 cases (5.5 %). There were statistically significant improvements in all speech score parameters. Hypernasality mean score changed from 3.36 ± 0.60 to 1.82 ± 1.22 (p < 0.001), nasal emission from 1.9 ± 0.88 to 0.88 ± 0.32 (p = 0.015) and the intelligibility from 2.68 ± 0.65 to 1.48 ± 1.16 (p = 0.045). The mean follow up period after the procedure was 23.9 ± 14 months. The age of surgery (p = 0.034), diagnosis (p = 0.004), fistula (p = 0.038) and preoperative nasality score (p = 0.033) were the significant predictive factors affecting outcome. PPAP + Re:IVVP is a modified procedure for VPI showing significant improvement in all speech scores and might be best suitable for short pliable palates. Further study is needed for a clearer description of patient selection to optimize outcomes.
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http://dx.doi.org/10.1016/j.jcms.2025.04.002 | DOI Listing |
Semin Ultrasound CT MR
September 2025
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:
Fetal magnetic resonance imaging (MRI) is a safe method of in-utero evaluation of fetal anomalies and a valuable adjunct to prenatal ultrasound. The utilization of rapid sequences reduces the impact of fetal motion and allows for high contrast resolution of fetal structures. A thorough understanding of fetal anatomy and a systematic approach to MRI interpretation are essential for accurate diagnosis of fetal head and neck anomalies.
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
Faculty School of Human Medicine, Peruvian University Union (UpeU), Lima, Peru.
Objective: Most of the studies support that primary rhinoplasty during cleft-lip repair results in good outcomes with no effects on nasal growth. This study, through the analysis of patients with congenital unilateral cleft lip, explores the efficacy of the vestibular Z-plasty technique for primary nasal deformity repair.
Methods: Since 2023, a single surgeon has operated on 12 consecutive unilateral cleft lip and palate patients with associated nasal deformities.
J Anat
September 2025
Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Katowice, Poland.
Vertebrates exhibit remarkable morphological diversity, with the head representing an exceptionally complex anatomical structure shaped by adaptations to feeding ecology, brain size, and sensory organ specialization. Proper fusion of facial prominences and the coordinated growth of the skull and brain are essential for normal craniofacial development in vertebrates, including humans. Disruptions in these processes, whether due to gene mutations or external factors, can result in craniofacial malformations.
View Article and Find Full Text PDFAesthetic Plast Surg
September 2025
Faculty of Medicine and Health Sciences (FMHS), Plastic, Aesthetic and Reconstructive Surgery Unit, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia.
Introduction: Unilateral cleft lip nasal (UCL/N) deformity severity presents complex anatomical challenges, with surgical outcomes influenced by preoperative status. Existing classification systems for UCL/N lack standardization, relying on subjective clinical assessments or isolated anthropometric measures that fails to assess anatomical deformity comprehensively. This limits their utility in objectively stratifying deformity severity and justifying postoperative outcomes.
View Article and Find Full Text PDFJ Med Cases
August 2025
Internal Medicine Department, Unidade Local de Saude de Sao Joao, Alameda Professor Hernani Monteiro, 4200-319 Porto, Portugal.
Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, carefully monitored by healthcare providers due to its potential adverse effects. As a result, methotrexate toxicity is relatively rare. We present the case of a 79-year-old man followed in rheumatology for symmetrical polyarthralgia, who inadvertently took methotrexate 10 mg daily, instead of weekly, leading to methotrexate toxicity.
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