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Article Abstract
Introduction: Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.
Methods: At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.
Results: AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.
Discussion: AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994863 | PMC |
| http://dx.doi.org/10.3389/fnagi.2025.1508677 | DOI Listing |
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