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Stroke is the fifth leading cause of death in Taiwan. In the process of stroke treatment, rehabilitation for gait recovery is one of the most critical aspects of treatment. The Gait Assessment and Intervention Tool (G.A.I.T.) is currently used in clinical practice to assess the gait recovery level; however, G.A.I.T. heavily depends on physician training and clinical judgment. With the advancement of technology, today's small, lightweight inertial measurement unit (IMU) wearable sensors are rapidly revolutionizing gait assessment and may be incorporated into routine clinical practice. In this paper, we developed a gait data acquisition and analysis system based on IMU wearable devices, proposed a simple yet accurate calibration process to reduce the IMU drifting errors, designed a machine learning algorithm to obtain real-time coordinates from IMU data, computed gait parameters, and derived a formula for G.A.I.T. scores with significant correlation with the physician's observational scores.
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http://dx.doi.org/10.3390/s25071994 | DOI Listing |
Spine (Phila Pa 1976)
October 2025
Niigata Spine Surgery Center, Kameda Daiichi Hospital, Niigata, Japan.
Study Design: Prospective cohort study.
Objective: To investigate longitudinal changes in physical functional status after long corrective fusion in patients with adult spinal deformity (ASD) during 2 years of follow-up.
Background: In ASD surgery, reports assessing physical functional status in long-term observations for more than a year are lacking.
Ann Neurol
September 2025
Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Objective: Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair-bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor control center, modulates the activity of spinal locomotor centers via the reticulospinal tract. Even with severe corticospinal damage, the widely distributed reticulospinal fibers frequently cross the lesion, and lumbosacral spinal locomotor centers remain responsive.
View Article and Find Full Text PDFNEJM AI
September 2025
Department of Bioengineering, Stanford University, Stanford, CA.
Background: Assessing human movement is essential for diagnosing and monitoring movement-related conditions like neuromuscular disorders. Timed function tests (TFTs) are among the most widespread types of assessments due to their speed and simplicity, but they cannot capture disease-specific movement patterns. Conversely, biomechanical analysis can produce sensitive disease-specific biomarkers, but it is traditionally confined to laboratory settings.
View Article and Find Full Text PDFJ Vet Intern Med
September 2025
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Ontario, Canada.
Background: Sudden cardiac death is common in racehorses. Factors associated with the QT interval that could predispose to fatal cardiac arrhythmias are unknown. Cardiac restitution, expressed as a ratio of QT/TQ, has been used in humans to assess arrhythmia risk but has not been described in horses during maximal intensity exercise.
View Article and Find Full Text PDFFluids Barriers CNS
September 2025
Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
Background: Idiopathic normal pressure hydrocephalus (iNPH) predominantly manifests with gait disturbances, yet clinical assessments are vulnerable to confirmation bias, particularly post-shunt surgery. Blinded video evaluations are a method to enhance objectivity in gait assessment, but their reliability has never been systematically investigated. The aim was to evaluate the inter-rater reliability of blinded gait assessments in iNPH patients and to investigate how these assessments correlate with the Hellström iNPH scale and patient-reported health status following shunt surgery.
View Article and Find Full Text PDF