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| http://dx.doi.org/10.23736/S0375-9393.25.18873-1 | DOI Listing |
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Combined inflation and cooling method improves lung function in uncontrolled donation after circulatory death.
J Thorac Cardiovasc Surg
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Department of General Thoracic and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Electronic address:
Objective: Currently, the two methods used to preserve lungs from uncontrolled donation after circulatory death-topical cooling and inflation-result in the suboptimal utilization of lungs. This study aimed to introduce an approach that combines cooling and inflation to investigate whether it improves lung conditions in a swine model, even if the lungs had been damaged with long-term warm ischemia, such as in out-of-hospital cardiac arrest.
Methods: Donor lungs subjected to 1.
Capnometry predicts the viability of procured kidneys from uncontrolled donation after circulatory death donors.
Resuscitation
August 2025
School of Medicine, Universidad Complutense, Madrid, Spain; Department of Nephrology, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain.
Introduction: Although uncontrolled donation after circulatory death (uDCD) donors provide kidney transplants with excellent long-term survival rates, a significant percentage of grafts are eventually found not to be viable for transplantation. Capnometry during cardiopulmonary resuscitation (CPR) is a marker of tissue metabolism and organ perfusion. We analyzed whether capnometry values in potential uDCD donors could help to differentiate between valid (who provided at least one transplantable kidney) and futile uDCD donors (those not yielding suitable grafts for transplantation).
View Article and Find Full Text PDFPreservation Fluid Bacteriology in Kidney Transplantation: Comparing Uncontrolled Donation After Circulatory Death With Donation After Brain Death.
Transpl Int
August 2025
Urology Department, University Hospital Center of São João, Porto, Portugal.
Infectious complications remain a significant concern in organ transplantation, and preservation fluid (PF) has been identified as a potential source of microbial contamination. However, the clinical relevance of positive PF cultures, especially in kidney transplants from uncontrolled donation after circulatory death (uDCD), is not clearly established. This study aims to evaluate and compare the incidence and clinical implications of positive PF cultures in kidney transplants from uDCD and donation after brain death (DBD) donors.
View Article and Find Full Text PDFNew Donor Selection Criteria Result in Optimal Outcomes of Kidneys from Uncontrolled Donation After the Circulatory Determination of Death.
Transplant Direct
May 2025
Transplant Coordination Unit and Service of Intensive Care, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.
Background: The aim of our study is to share our experience with uncontrolled donation after the circulatory determination of death (uDCDD) kidney transplantation and to propose updated donor selection criteria for uDCDD programs.
Methods: A prospective study comparing kidney recipients of grafts from local uDCDD donors with recipients of grafts from local standard criteria donors after the neurological determination of death (DNDD) between 2013 and 2024. Donor acceptance was determined using a combination of 3 factors: donor age, no-flow period, and warm ischemic time (WIT).
Factors of time and genetics influencing the rate of monozygotic twinning following ART.
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Nilo Frantz Reproductive Medicine, Porto Alegre, RS, Brazil.
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