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Article Abstract
A one-pot synthesis of chiral multifunctional oxazole frameworks is accomplished a cascade reaction involving an anionic stereogenic cobalt(III) complex-catalyzed enantioselective Ugi four-component/Wittig process. This approach tolerates a complex reaction system that includes aldehydes, amines, carboxylic acids, and isocyano-(triphenylphosphoranylidene)acetates, yielding chiral 2,4,5-trisubstituted oxazoles with good enantioselectivities (up to 93 : 7 er).
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| http://dx.doi.org/10.1039/d5ob00293a | DOI Listing |
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