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In this study, a benzothiazole-based fluorescent probe, (methyl (E)-2-(3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-me$thylbenzylidene) hydrazine-1-carboxylate) (DYH), was investigated for the possibility of sensitive detection of potentially threatening explosives (2, 4, 6-trinitrophenol) TNP and its application. The probe exhibited blue-green fluorescence in methanol solution and its intensity decreased significantly with increasing TNP concentration, achieving a fluorescence quenching efficiency of up to 99.77%. The binding between the probe and TNP followed a stoichiometric ratio of 1:1, achieving a detection limit of approximately 2.1 × 10 M, indicating its high detection sensitivity. Further studies have shown that the DYH was excellent in rapidly detecting TNP, and its application in natural water samples and solid phase papers validated its usefulness. In addition, this study successfully combined the probe DYH with smartphone technology, establishing a convenient smartphone sensing platform that provides a more convenient solution for rapid and real-time detection of TNP.
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http://dx.doi.org/10.1007/s10895-025-04270-6 | DOI Listing |
J Fluoresc
September 2025
School of Medical Technology and Artificial Intelligence, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China.
Excessive aluminum ions (Al) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al.
View Article and Find Full Text PDFInorg Chem
August 2025
Department of Chemistry, Indian Institute of Technology Tirupati, Tirupati, Andhra Pradesh 517619, India.
Hydrogen peroxide regulates tyrosinase activity, a key enzyme in melanogenesis, underscoring the importance of redox balance in melanin biosynthesis. A new class of thiazole- and benzothiazole-based selones and their sulfur analogues was synthesized and structurally characterized, with the selones showing potent mushroom tyrosinase inhibition and significantly lower IC values than those of kojic acid. Benzothiazole-based selone (IC = 0.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Sichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Xihua University, Chengdu, 610039, China.
DBr-Ma, a novel benzothiazole-based fluorescent sensor modified with dicyanide groups, shows exceptional sensitivity and discrimination for biogenic amines (especially spermine/cadaverine), exhibiting a 150-fold sensitivity increase over DBr-CHO. Validated by DFT, HRMS, NMR, and spectroscopy, the gel sensor PD@Ma enables real-time monitoring of seafood spoilage, advancing food safety.
View Article and Find Full Text PDFJ Fluoresc
July 2025
Department of Chemistry, Rajalakshmi Engineering College, Chennai, 602105, India.
Thiazole derivatives have emerged as powerful scaffolds in the design of chemosensors due to their excellent photophysical properties, structural versatility, and strong coordination capabilities with various toxic ions. Recent advances have demonstrated significant improvements in the development of selective and sensitive chemosensors targeting environmentally and biologically hazardous ions such as Hg⁺, Pb⁺, Cd⁺, As⁺, CN⁻, and F⁻. This review highlights the latest progress in the design and application of thiazole/benzothiazole-based chemosensors, focusing on their sensing mechanisms-including photoinduced electron transfer (PET), intramolecular charge transfer (ICT), and fluorescence resonance energy transfer (FRET)-as well as strategic modifications to enhance selectivity, sensitivity, and water solubility.
View Article and Find Full Text PDFFood Chem
October 2025
Food Microbiology Key Laboratory of Sichuan Province, Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China; Sichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Department of Chemistry, Xihua Unive
Here, we present BTPC-Ta, a benzothiazole-based fluorescent sensor enabling ultrasensitive detection of biogenic amines (spermine/cadaverine: 0.1 nM) through visible colorimetric transitions (red-to-blue). Supported by DFT calculations, HRMS, and NMR analyses, the sensing mechanism involves structural reorganization upon analyte binding.
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