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Chronic disease (CD) like diabetes and stroke impacts global healthcare extensively, and continuous monitoring and early detection are necessary for effective management. The Metaverse Environment (ME) has gained attention in the digital healthcare environment; yet, it lacks adequate support for disabled individuals, including deaf and dumb people, and also faces challenges in security, generalizability, and feature selection. To overcome these limitations, a novel probabilistic-centric optimized recurrent sechelliott neural network (PO-RSNN)-based diabetes prediction (DP) and Fuzzy Z-log-clipping inference system (FZCIS)-based severity level estimation in ME is carried out. The proposed system integrates Montwisted-Jaco curve cryptography (MJCC) for secured data transmission, Aransign-principal component analysis (A-PCA) for feature dimensionality reduction, and synthetic minority oversampling technique (SMOTE) to address data imbalance. The diagnosed results are securely stored in the BlockChain (BC) for enhanced privacy and traceability. The experimental validation demonstrated the superior performance of the proposed system by achieving 98.97% accuracy in DP and 98.89% accuracy in stroke analysis, outperforming existing classifiers. Also, the proposed MJCC technique attained 98.92% efficiency, surpassing the traditional encryption models. Thus, the proposed system produces a secure, scalable, and highly accurate DP and stroke analysis in ME. Further, the research will extend the approach to other CD like cancer and heart disease to improve the predictive performance.
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http://dx.doi.org/10.1038/s41598-025-96541-2 | DOI Listing |
Eur Geriatr Med
September 2025
School of Public Health Sciences, University of Waterloo, Waterloo, Canada.
Purpose: Sleep disturbance is prevalent in long-term care facilities (LTCFs), yet there is limited understanding of individual factors predicting changes in sleep within these populations. Our objective was to determine predictors of sleep disturbance in LTCFs and investigate variation in prevalence across facilities in two Canadian provinces-New Brunswick and Saskatchewan.
Method: This retrospective longitudinal cohort study used interRAI comprehensive health assessment data from 2016 to 2021, encompassing 21,394 older adults aged ≥ 65 years across 228 LTCFs.
Acta Neurochir (Wien)
September 2025
Department of Neurosurgery, Medical University of Gdańsk, Gdańsk, Poland.
Purpose: Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive arterial stenosis and fragile collateral formation, elevating stroke risk. Revascularization is the standard treatment, yet up to 27% of patients experience ischemic events within a year due to bypass insufficiency. While digital subtraction angiography (DSA) remains the gold standard for assessing bypass function, it is invasive and time-consuming.
View Article and Find Full Text PDFFunct Integr Genomics
September 2025
The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China.
Ischemic stroke (IS) has high morbidity/mortality with limited treatments. This study screened core copper homeostasis-related genes in IS and validated their function as precise intervention targets. Human IS gene chip data were retrieved from GEO, and copper homeostasis genes from multiple databases.
View Article and Find Full Text PDFClin Res Cardiol
September 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, Center for Translational and Experimental Cardiology (CTEC), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.
Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.
Int J Surg
September 2025
Department of Cardiovascular Surgery, The Affiliated Hospital, Southwest Medical University, Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Key Laboratory of Cardiovascular Remodeling and Dysfunction, Luzhou, Sichuan, PR China.
Objective: This meta-analysis aimed to compare the perioperative safety and efficacy of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in bicuspid aortic valve (BAV) stenosis.
Methods: We systematically analyzed studies from PubMed, Cochrane Library, Embase, and CNKI comparing TAVR and SAVR in BAV stenosis. Outcomes included postoperative mortality, complications, all-cause survival, and freedom from stroke.