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Article Abstract
Acinetobacter baumannii is a well-known opportunistic gram-negative bacterium responsible for serious concerns to human health due to its high virulence and extensive resistance to numerous antibiotics such as carbapenem, colistin, tigecycline, and many more. Herein, we have conducted the first total synthesis of the repeating unit of Acinetobacter baumannii strain K141 via the convergent [2 + 2] approach featuring the coupling of β-L-Rhap-(1 → 4)-β-D-GlcpNAc and β-D-Galp-(1 → 3)-β-D-GlcpNAc units. The synthesis of the first disaccharide unit involved a stereoselective cis-rhamnosylation that was achieved via the picoloyl-induced hydrogen bond mediated aglycon delivery with high β-stereo control.
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| http://dx.doi.org/10.1016/j.carres.2025.109478 | DOI Listing |
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