98%
921
2 minutes
20
[This corrects the article DOI: 10.1371/journal.pone.0318845.].
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970663 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0322030 | PLOS |
J Psychiatr Res
September 2025
Department of Behavioral Sciences, Faculty of Medicine, University of Debrecen, 22. Móricz Zs. Blvd., Debrecen, 4032, Hungary. Electronic address:
Background: Adversities suffered at an early age lead to negative long-term effects impacting the development of the emotional, social, and cognitive domains of the personality, including metacognitive skills.
Objective: We aimed to investigate the mediating role of metacognition in the impact exercised by early adversities on trait anxiety.
Participants: Participants (all over 18) were recruited from the general population (n = 304).
Front Neurosci
July 2025
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Introduction: The anterior insular cortex (AIC) integrates interoceptive, cognitive-emotional, and error-monitoring signals, and is consistently hyperactive in anxiety and depression. Converging evidence links elevated glutamate + glutamine (Glx) in fronto-insular regions to stress reactivity; however, it is unknown whether AIC Glx relates to a transdiagnostic general psychopathology factor (G-score) or to the tendency to overweight prediction errors during learning. We therefore combined functional MRS (fMRS) with reinforcement-learning modeling to test whether (i) baseline AIC Glx predicts the G-score derived from bifactor analysis of PHQ-9, GAD-7, and STAI-X1, and (ii) task-evoked Glx changes track individual differences in error sensitivity during gain- and loss-based learning.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
July 2025
Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.
View Article and Find Full Text PDFJ Headache Pain
July 2025
Department of Neurology, Danish Headache Center, Copenhagen University Hospital- Rigshospitalet, Copenhagen, Denmark.
Background: Persistent post-traumatic headache (PPTH) frequently resembles migraine but may involve distinct white matter perturbations. We compared white matter fiber tracts among adults with PPTH, migraine, and healthy controls (HCs).
Methods: This cross-sectional diffusion tensor imaging (DTI) study enrolled adults with PPTH, migraine, and HCs, who underwent a single 3T MRI session.