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Background: Overloading of the elbow joint is one of the mechanisms responsible for failure of total elbow arthroplasty (TEA). Different activities of daily living (ADL) affect joint loading. However, the alteration in task execution and its impact on joint loads after TEA are not well understood. This study investigates differences between TEA patients and healthy controls in task execution and associated joint loads during simulated ADL.
Methods: TEA patients (n = 7) and healthy controls (n = 18) performed 8 simulated ADL tasks. Using musculoskeletal modeling software (OpenSim), joint angles and moments were calculated and joint power was assessed. A mixed model statistical design was performed to determine group and tasks differences.
Results: TEA patients showed reduced flexion-extension (FE) range of motion (60.6° ± 25.6 vs. 44.9° ± 19.9, = .003). Interaction effects between groups and tasks for joint load and peak power were observed. Particularly during rising from a chair, patients showed reduced FE moment (5.7 Nm vs. 14.5 Nm, = .026), varus-valgus moment (6.0 Nm vs. 14.3 Nm, = .036), and peak power (3.6 Watt vs. 20.1 Watt, = .036) compared to healthy controls.
Conclusion: TEA patients differ from healthy controls in task execution of ADL tasks regarding the functional elbow FE angle over all 8 ADL tasks and in joint load and peak power for the more straining tasks. The power plots visualizes differences in movement strategy that are of interest for future research on possible training of TEA patients, or prosthesis design, aimed to improve ADL function and enhance prosthesis survival rates.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962619 | PMC |
http://dx.doi.org/10.1016/j.jseint.2024.10.017 | DOI Listing |
Purpose: Combinatorial therapies are essential for treating advanced non-small cell lung cancer (NSCLC), particularly overcoming resistance to third-generation epidermal growth factor receptor (EGFR) like osimertinib (OSI). The Hippo signaling pathway, a critical regulator of cell proliferation, apoptosis, and tumor progression, is often dysregulated in NSCLC and contributes to chemo-resistance. This study investigated the potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, to overcome OSI resistance by modulating the Hippo signaling pathway, specifically through inhibition of the YAP-1 (Yes-associated protein)-TEAD (TEA domain transcription factor)-CTGF (connective tissue growth factor) axis.
View Article and Find Full Text PDFACS Omega
September 2025
Department of Electrical and Computer Engineering, North South University, Bashundhara, Plot # 15, Dhaka Division, Dhaka 1229, Bangladesh.
Air pollution is a critical threat to human health and the quality of life in large cities. In this work, we electrically characterized indoor air quality in Dhaka City with a microcontroller-based advanced sensing system in the presence of 60 air purifiers. We conducted LabVIEW-controlled, fully automated, and remotely operated experiments to precisely monitor, store, and analyze the air-purifying effects in the concentrations of air quality index (AQI) parametersPM2.
View Article and Find Full Text PDFFront Nutr
August 2025
Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Introduction: Olive leaf has strong antibacterial and anti-inflammatory properties, potentially modulating gut microbiota composition. This may help address small intestinal bacterial overgrowth (SIBO), a gastrointestinal (GI) problem causing malabsorption and potential complications.
Objective: This study aimed to observe the effect of olive leaf tea (OLT) on GI symptoms, body composition, and the hydrogen/methane breath test among patients suffering from SIBO.
Shoulder Elbow
September 2025
Getting it Right First Time Programme, NHS England, London, UK.
Background: Total elbow arthroplasty (TEA) is a low-volume, high-complexity procedure and clinical guidelines recommend moving to a centralised network model. The aim of the study was to assess the effect of surgeon and unit volume on patient and service level clinical outcomes.
Methods: Analysis the Hospital Episodes Statistics database (HES) for elective and emergency primary TEA surgery between January 2014 and December 2023 was performed.
World J Methodol
December 2025
Department of Trauma and Emergency Medicine, All India Institute of Medical Sciences, Bhopal 462024, Madhya Pradesh, India.
Background: Chest physiotherapy and incentive spirometry, essential for pulmonary care, can exacerbate acute post-thoracotomy pain. Pain relief is, therefore, essential to facilitate early mobilization. This study evaluated the analgesic efficacy of unilateral continuous erector spinae block (ESB) compared to thoracic epidural analgesia (TEA) in terms of quality of pain relief and perioperative hemodynamic changes.
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