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http://dx.doi.org/10.4269/ajtmh.24-0213 | DOI Listing |
Org Lett
September 2025
Graduate School of Science and Engineering, Ehime University, Matsuyama 790-8577, Japan.
A fused octapyrrolylanthracene, representing a nonplanar pyrrole-fused aza-nanographene with two deep gulf-edge regions, was readily synthesized and found to exhibit a ladder-shaped bent structure. Electrochemical studies revealed reversible multielectron oxidation up to four electrons. Stepwise oxidation with AgPF or I afforded a singlet diradical dication and a closed-shell aromatic tetracation.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
Department of Applied Chemistry, College of Science, China Agriculture University, Beijing 100091, China.
l-glufosinate has garnered increasing attention as an ideal herbicide for weed control in agriculture. However, the underlying racemization process of l-glufosinate in the aqueous phase remains unclear. In this work, we elucidated the racemization mechanisms through heating reactions and theoretical calculations.
View Article and Find Full Text PDFClin Transl Sci
September 2025
Food and Drug Administration, Silver Spring, Maryland, USA.
Since the first decentralized clinical trial (DCT) was conducted in 2011, there has been an increased usage of DCT due to its benefits of patient-centricity and generalizability of findings. This trend was further expedited by the global COVID-19 pandemic. We identified 23 case studies across various therapeutic areas and grouped them into different categories according to their purposes-by necessity, for operational benefits, to address unique research questions, to validate innovative digital endpoints, or to validate decentralization as a clinical research platform.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Social Epidemiology, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan.
Importance: Previous studies have suggested that social participation helps prevent depression among older adults. However, evidence is lacking about whether the preventive benefits vary among individuals and who would benefit most.
Objective: To examine the sociodemographic, behavioral, and health-related heterogeneity in the association between social participation and depressive symptoms among older adults and to identify the individual characteristics among older adults expected to benefit the most from social participation.
J Empir Res Hum Res Ethics
September 2025
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Biobanking in China has seen rapid development, placing the country as a key player globally. However, significant ethical challenges arise, particularly around donor autonomy in informed consent for collecting and using biological materials and personal data. This study examines how Chinese biobanks inform donors about their participation and the ethical content of consent documents.
View Article and Find Full Text PDF