98%
921
2 minutes
20
Background: There is a substantial body of literature addressing the prevention, acute management, and follow-up care of radiation induced dermatitis (RID). The quality and application of this evidence, however, is inconsistent and its interpretation varies widely. While several national guidelines have been developed to standardise practices locally, many of these resources are not publicly available. On behalf of the European Society for Radiotherapy and Oncology (ESTRO) Radiation Therapist (RTT) Committee, an international writing group consisting of 12 experts from radiotherapy and two patient representatives composed a recommendation document for the management of RID.
Main Body: The consensus for these recommendations was generated based on available international guidelines, and supplemented with evidence-based review articles on the topic. These recommendations focus on the prevention and practical management of early stage RID by avoiding skin trauma and maintaining hygiene. Addressing pain and inflammation in higher grades is also covered. The current literature refutes some of the traditional recommendations, especially restricting washing as well as the use of deodorant or the potential dose build-up of lotions which has been included and rectified in recent guidelines. In addition, the importance of grading the severity, including a baseline assessment is presented. The benefit of clear, and non-contradictory communication within the multidisciplinary team as well as patient involvement (e.g. PROMs or similar) is highlighted. Furthermore, the importance of recognising different skin types and skin tones, and the impact on how RID changes these in their appearance is stressed.
Conclusion: This document provides practical, actionable recommendations for the clinical management of RID, referencing the supporting literature. These recommendations have, however, identified a lack of high-level evidence, especially for agent-specific recommendations.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954187 | PMC |
http://dx.doi.org/10.1186/s13014-025-02624-9 | DOI Listing |
BMC Public Health
August 2025
Department of Geography, Environment and Geomatics, University of Ottawa, 60 University, K1N 6N5, ON, Ottawa, Canada.
Background: A Black Geographies framework offers a perspective through which the rich and complex histories and knowledges of African nations, and the people themselves, can be explored to reveal barriers to vaccination and solutions to achieving global vaccine access and equity. This research centres Malawi as a case study and seeks to (1) identify barriers to COVID-19 vaccination; (2) situate these barriers within geographic scales, ranging from the local to the global; and, (3) identify the role of the (Black) individual in creating, perpetuating, navigating and overcoming these barriers.
Methods: The study employed a qualitative approach, using in-depth semi-structured interviews with 41 key informants in Malawi between September and December 2021 to explore barriers to vaccination.
BMC Health Serv Res
July 2025
Department of Business Administration and Information Systems, Addis Ababa University, Addis Ababa, Ethiopia.
Background: Healthcare systems continue to grapple with preventable patient safety challenges that require leadership interventions across all levels of operation. Servant leadership has emerged as a promising style for cultivating an organizational culture that promotes patient safety improvement within healthcare settings. This study explored how healthcare managers' servant leadership behaviors contribute to nurturing an organizational culture that boosts patient safety performance in public healthcare settings.
View Article and Find Full Text PDFAIDS Res Ther
July 2025
University of East Anglia, Norwich, UK.
Malawi is among the countries with the highest HIV prevalence worldwide. Adolescents living with HIV (ALHIV) face diverse challenges, which influence their emotional wellbeing and long-term health, in addition to impacting HIV onward transmission. HIV education, especially the use of fear-based animation, but also the figurative language used for HIV, contribute to how ALHIV perceive and respond to their HIV status.
View Article and Find Full Text PDFStem Cell Res Ther
July 2025
Department of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
The irreversible erosion of X-chromosome inactivation (XCI) due to repression of the long non-coding RNA XIST presents a major challenge for disease modeling and raises safety concerns for the clinical application of female human pluripotent stem cells (hPSCs) due to the aberrant overexpression of X-linked genes. While Cas9-mediated non-homologous end joining (NHEJ) targeting the XIST promoter can induce DNA demethylation and restore XCI by reactivating XIST, its efficiency remains low. Here, we introduce a highly efficient strategy for XIST reactivation by combining TP53 inhibition with suppression of DNA methylation maintenance during Cas9-mediated NHEJ.
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
May 2025
Genetic Medicinal Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi 710061, China.
Objective: To investigate the X-chromosome inactivation (XCI) patterns and origin in four children with Rett syndrome (RTT), and to explore the genetic basis of their phenotypic variability.
Methods: Four pediatric RTT cases diagnosed at Northwest Women's and Children's Hospital between August 1, 2022 and October 31, 2024 were enrolled. Clinical data were collected, and whole exome sequencing (WES) and Sanger sequencing were performed on the children and their parents to identify pathogenic variants.