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http://dx.doi.org/10.1016/j.ihj.2025.03.013 | DOI Listing |
Microbiol Spectr
September 2025
Department of Clinical Microbiology, Hospital Clínic of Barcelona-ISGlobal, University of Barcelona, Barcelona, Spain.
Unlabelled: Accurate methods to assess viral viability are crucial for determining isolation duration and antiviral therapy in immunocompromised patients. Although cell culture (CC) is the gold standard, it has limitations. Cycle threshold (Ct) values from genomic RNA (gRNA) RT-PCR and subgenomic RNA (sgRNA) RT-PCR have been proposed as markers of active viral replication.
View Article and Find Full Text PDFBackground: Thiopurine S-methyltransferase (TPMT) is crucial for metabolising thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified clinically applicable thresholds to distinguish individuals with normal TPMT function from those with reduced or deficient activity.
View Article and Find Full Text PDFGenet Med Open
July 2025
Faculty of Biology Medicine and Health, University of Manchester, United Kingdom.
Purpose: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to analyze the genotype distribution of FCS-causing genes in the United Kingdom.
Methods: Data were anonymously collated from 2 genetic testing laboratories providing national genetic diagnosis services for severe hypertriglyceridemia in the United Kingdom.
Transl Neurosci
January 2025
The Affiliated Brain Hospital, Guangzhou Medical University, No. 36, Ming Xin Road, Guangzhou, Guangdong, P. R. China.
Background: Multiple sclerosis (MS) is a major demyelinating disorder that affects the central nervous system. A growing body of evidence has revealed the involvement of coagulation pathway in the pathogenesis of MS. However, the causal association between coagulation factors and MS is still unclear.
View Article and Find Full Text PDFCureus
August 2025
Medicine/Cardiology, Madigan Army Medical Center, Tacoma, USA.
Apical hypertrophic cardiomyopathy (ApHCM) is an uncommon, nonobstructive form of hypertrophic cardiomyopathy (HCM) that is associated with an increased risk of ventricular aneurysms, atrial fibrillation, heart failure, and cardiac death. In this case report, a 63-year-old male patient was found to have deeply negative T waves on electrocardiogram (EKG) during a routine preoperative evaluation in an outpatient internal medicine clinic. Imaging with echocardiography and cardiac magnetic resonance confirmed the diagnosis of ApHCM.
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