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Despite the advancement in the left ventricular assist devices (LVADs), right heart failure (RHF) remains a challenging adverse event after LVAD implantation and is associated with increased morbidity and mortality. In this study, we sought to assess the role of cardiac magnetic resonance-derived right ventricular ejection fraction (CMR-RVEF) in predicting the risk of post-LVAD RHF. Overall baseline characteristics and clinical outcomes were compared between the patients who developed post-LVAD RHF and those who did not. A total of 42 patients who underwent CMR before LVAD implantation were included in this study. The mean CMR-RVEF was 25 ± 13%, with no statistically significant difference between the 2 groups (27.7 ± 13.9% vs 24.5 ± 12.3, = 0.5). The mean of the CMR-derived right ventricular volume index trend was higher in those with post-LVAD RHF (76 ± 28 ml/m vs 65 ± 25 ml/m; = 0.31). In conclusion, in patients who underwent CMR before LVAD implantation, CMR-RVEF may not predict post-LVAD RHF. Large multicenter studies are needed to confirm this finding.
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http://dx.doi.org/10.1016/j.jhlto.2024.100056 | DOI Listing |
J Cardiovasc Dev Dis
July 2025
Faculty of Medicine, Department of Cardiac Surgery, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Unlabelled: Heart failure (HF) and left ventricular hypertrophy (LVH) are linked to fibroblast growth factor 23 (FGF23). This study aims to analyze whether FGF23 can predict postoperative outcomes in unselected left ventricular assist device (LVAD) candidates.
Methods: We conducted a prospective observational study that included 27 patients (25 HeartMate3 and 2 HeartMateII) with a median follow-up of 30 months.
J Cardiovasc Dev Dis
June 2025
Department of Bioengineering, College of Engineering, Computing and Applied Sciences, Clemson University, Clemson, SC 29634, USA.
Right heart failure is a condition where the right ventricle fails to pump blood into the pulmonary artery, and, in turn, the lungs. This condition frequently presents after the implantation of a left ventricular assist device (LVAD). Ventricular assist candidates who have LVADs implanted possess various pathophysiological and cardiovascular features that contribute to the later development of RHF.
View Article and Find Full Text PDFJ Clin Med
May 2025
Faculty of Medicine, Department of Cardiac Surgery, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
: In the context of acute heart failure, proenkephalin A (penKid) has emerged as a prognostic marker for acute kidney injury (AKI), whereas bioactive adrenomedullin (bio-ADM) has been identified as a significant biomarker linked to shock and organ dysfunction. This raises the question of whether they can serve as predictors of postoperative complications in patients receiving left ventricular assist devices (LVADs). : This observational study prospectively enrolled patients who had received LVAD implantation.
View Article and Find Full Text PDFBMC Cardiovasc Disord
March 2025
Faculty of Medicine, Department of Cardiac Surgery, RWTH Aachen University, University Hospital Aachen, Aachen, Germany.
Background: Atrial fibrillation (AF) is prevalent among patients with left ventricular assist devices (LVADs); however, the exact influence of different types of AF on the clinical outcomes of these patients is unknown. The purpose of this study was to ascertain the impact of different types of AF on the outcomes of patients with LVADs.
Methods: The records of 162 patients with the LVADs HeartMate 3 (n = 64) and HeartMate II (n = 98) at a single center were reviewed.
JHLT Open
May 2024
Cardiovascular Center, Division of Cardiology, Tufts Medical Center, Boston, Massachusetts.
Background: Diuretic responsiveness is associated with heart failure disease progression. Among patients with advanced heart failure, we hypothesized that decreased diuretic responsiveness and higher diuretic requirement are correlates of progressive right ventricular dysfunction and may help to risk stratify patients undergoing left ventricular assist device (LVAD) evaluation.
Methods: We performed a single-center, retrospective analysis of 147 patients undergoing LVAD implantation between 2014 and 2018.