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The influence of surgeon expertise on patients' outcomes after repair of acute type A aortic dissection (ATAAD) is not well established. The aim of this paper is to report the results of ATAAD repair performed by expert (ES) and not expert aortic surgeons (NES) in our center. : We have retrospectively divided 199 patients into two groups according to the first surgeon experience (ES = 138 patients and NES = 61 patients), all being members of the aortic team. We evaluated and compared early and long-term outcomes. : Although the two groups were comparable in terms of clinical presentation and intraoperative setting, ES performed more aortic arch repairs (40% vs. 26%, = 0.06) and frozen elephant trunk procedures (15% vs. 3%, = 0.02), albeit with similar intraoperative times (median cardiopulmonary bypass time of 203 min in ES vs. 201 min in NES, respectively, = 0.88). The 30-day mortality was the same in the two groups (8%, = 1), and the postoperative course was similar except for a shorter in-hospital stay in the NES group (10 vs. 17 days, = 0.04). : In our experience, repair of ATAAD could be achieved with similar results between ES and NES. However, NES performed less technically demanding repairs. With standardization of pre-, intra-, and post-operative management, NES can be expected to increase their technical skills and be progressively involved in more complex ATAAD repairs without adversely affecting surgical results.
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http://dx.doi.org/10.3390/jcm14061819 | DOI Listing |
J Neurosci
September 2025
Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult male and female mouse retina. We found that S1P-related genes were dynamically regulated following retinal damage. (S1P receptor 1) and (sphingosine kinase 1) are expressed at low levels by resting MG and are rapidly upregulated following acute damage.
View Article and Find Full Text PDFBiomed Mater
September 2025
Department of Nanobiotechnology, Faculty of Biological Sciences, , Tarbiat Modares University, Tehran, P.O. Box 14115-154, Iran, Tehran, Tehran Province, 14115-154, Iran (the Islamic Republic of).
It is essential to develop new strategies for wound treatment and skin reconstruction, particularly by scaffolds that replicate the structure and function of native skin. A bilayer scaffold was developed using three-dimensional (3D) bioprinting, based on a uniform chitosan-based formulation for both layers, maintaining material uniformity while offering structural support and promoting cell adhesion. The upper chitosan layer, embedded with NHEK-Neo, is stiffer and mimics the epidermis, while the softer lower layer contains embedded HFFs and HFSCs, mimicking the dermis.
View Article and Find Full Text PDFACS Nano
September 2025
Department of Emergency and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou 215124, China.
Acute lung injury (ALI) is characterized by the excessive accumulation of reactive oxygen species (ROS), which triggers a severe inflammatory cascade and the destruction of the alveolar-capillary barrier, leading to respiratory failure and life-threatening outcomes. Considering the limitations and adverse effects associated with current therapeutic interventions, developing effective and safe strategies that target the complex pathophysiological mechanisms of ALI is crucial for improving patient outcomes. Herein, we developed an inhalable, multifunctional nanotherapeutic (MSCNVs@CAT) by encapsulating catalase (CAT) in mesenchymal-stem-cell-derived nanovesicles (MSCNVs).
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
September 2025
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ulcerative colitis (UC) is a serious inflammatory bowel disease with a significantly increasing incidence globally. Current treatment options often exhibit unstable efficacy and notable side effects, making the exploration of alternative therapies particularly important. Peucedanum praeruptorum Dunn, a traditional Chinese medicine, contains various bioactive compounds, among which praeruptorin A (PA) has garnered attention for its anti-inflammatory potential.
View Article and Find Full Text PDFJCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.