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Article Abstract
Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0-1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937394 | PMC |
| http://dx.doi.org/10.1038/s41598-025-95128-1 | DOI Listing |
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