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http://dx.doi.org/10.1111/acem.70027 | DOI Listing |
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFJB JS Open Access
September 2025
OLVG, Orthopedic Surgery Department, Amsterdam, the Netherlands.
Background: Evidence supporting surgery in elderly patients with distal radius fractures is limited, but displaced fractures may benefit from surgery. This study aimed to determine whether casting is noninferior to surgery for patients aged 65 years or older with substantially displaced intra-articular (AO type C) distal radius fractures.
Methods: This multicenter randomized controlled noninferiority trial included 138 patients (mean age 76 years, SD 6.
Cureus
September 2025
Internal Medicine, California Hospital Medical Center, Los Angeles, USA.
Delayed hemothorax (DHTX) is a possible sequelae of thoracic trauma, especially in the setting of patients being treated with anticoagulation. We report the case of an 81-year-old Caucasian man with a DHTX presenting 14 days following an initial emergency department (ED) visit with multiple rib fractures due to a fall from the patient's bed. Upon presentation to the ED a second time, the patient was hospitalized, tested positive for COVID-19, and on the second day of admission underwent video-assisted thoracoscopic surgery (VATS) without bleeding or other complications.
View Article and Find Full Text PDFSemin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, MaineHealth, Portland, ME. Electronic address:
As life expectancy increases, the prevalence of ruptured abdominal aortic aneurysms (rAAA) poses a significant challenge for our healthcare system. Aging induces biochemical changes, including degradation of the extracellular matrix and loss of vascular smooth muscle cells, which increase the propensity for the development of aneurysms and subsequent rupture due to compromised integrity of the aortic wall. The mortality rate for elderly patients presenting with rAAA is high, ranging from 80 to 90%.
View Article and Find Full Text PDFAlcohol Res
September 2025
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Purpose: Alcohol use disorder (AUD) and mild traumatic brain injury (mTBI) have a bidirectional, synergistic, and complicated relationship. Although it is difficult to definitively say that mTBI causes AUD, certain biological mechanisms that occur after trauma are also associated with hazardous alcohol use. Hazardous drinking is defined as any quantity or pattern of alcohol consumption that places people at risk for physical and/or psychological harm.
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