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Wireless recording and autoencoder denoising of intestinal activity in freely moving rats. | LitMetric

Wireless recording and autoencoder denoising of intestinal activity in freely moving rats.

J Pharmacol Sci

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo, 113-0033, Japan. Electronic address:

Published: May 2025


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Article Abstract

Conventional wired systems for recording intestinal motility using strain-gauge transducers physically limit animal movement and are not ideal for long-term studies. Here, we developed a wireless recording system that allows continuous monitoring of intestinal activity in freely moving rats. We also developed a denoising autoencoder that isolates intestinal motility signals from locomotor noise while maintaining a 10-s temporal resolution. The refined data revealed decreased intestinal motility while the rats were behaviorally active. This system has broad applications for in vivo physiological research.

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http://dx.doi.org/10.1016/j.jphs.2025.03.005DOI Listing

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