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http://dx.doi.org/10.1111/bju.16699 | DOI Listing |
Pediatr Nephrol
September 2025
Pediatric Nephrology Department, Biobizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
Copeptin, a stable glycopeptide derived from the precursor of arginine vasopressin (AVP), has emerged as a valuable surrogate biomarker for AVP due to its stability and ease of measurement. This narrative review explores the physiological role of copeptin, its utility as a diagnostic and prognostic biomarker in different kidney diseases, and its clinical relevance in renal tubular disorders. The clinical application of copeptin as a diagnostic biomarker is best established in the differential diagnosis of polyuria-polydipsia syndrome (PPS), distinguishing nephrogenic diabetes insipidus (NDI) from central diabetes insipidus (CDI) and primary polydipsia (PP).
View Article and Find Full Text PDFAllergol Immunopathol (Madr)
September 2025
Department of Respiratory Disease, Children's Hospital Affiliated to Shandong University, Jinan, China.
Background: Asthma is a chronic respiratory disease with complex pathogenesis. Some studies suggest that certain trace metals may be associated with asthma. However, the relationship between serum copper (Cu) and childhood asthma remains unclear.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Jaber Al-Ahmad Hospital, Al Jahra, KWT.
Heart failure (HF) remains a global health challenge with high morbidity and mortality, necessitating reliable biomarkers for risk stratification. The platelet-to-lymphocyte ratio (PLR), an emerging inflammatory marker, has shown prognostic potential in cardiovascular diseases, but its utility in HF remains inconsistently reported. This systematic review synthesizes evidence on PLR's prognostic value in HF, focusing on mortality, hospitalization, and its role in multimarker models.
View Article and Find Full Text PDFArch Phys Med Rehabil
September 2025
Department of Physical Therapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain; Grupo InPhysio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. Electronic address:
Objective: To evaluate the neurophysiological effects associated with dry needling. This review evaluates the influence of dry needling on pain-related biomarkers, conditioned pain modulation, and temporal summation to clarify the potential mechanisms underlying its therapeutic effects.
Data Sources: A literature search across the Physiotherapy Evidence Database (PEDro), Web of Science, PubMed, Cochrane Library, and Scopus databases until October 2024 was conducted.
Front Hum Neurosci
August 2025
Signal Processing Laboratory (LTS5), École Polytechnique Féderale de Lausanne (EPFL), Lausanne, Switzerland.
Introduction: Absence of language development is a condition encountered across a large range of neurodevelopmental disorders, including a significant proportion of children with autism spectrum disorder. The neurobiological underpinnings of non-verbal ASD (nvASD) remain poorly understood.
Methods: This study employed multimodal MRI to investigate white matter (WM) microstructural abnormalities in nvASD, focusing on language-related pathways.