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http://dx.doi.org/10.21037/tcr-24-1869 | DOI Listing |
Phys Med
August 2025
Sapienza, University of Rome, Department of Scienze di Base e Applicate all'Ingegneria, Rome, Italy; National Institute of Nuclear Physics, INFN, Section of Rome I, Rome, Italy.
Background And Purpose: As the incidence and mortality rates of pancreatic cancer continue to rise, the search for effective treatments is becoming increasingly urgent. Among the therapeutic approaches, highly hypofractionated stereotactic treatments are being explored. This paper explores the potential of Very High Energy Electrons (VHEE) in the range of 80-130 MeV, in light of recent advances in compact accelerator technology and its compatibility with ultra-high dose rate (UHDR) delivery.
View Article and Find Full Text PDFCureus
July 2025
Biomed Laboratory, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Introduction: Stereotactic radiotherapy is currently an essential therapeutic tool in the treatment of brain metastases. The aim of our study was to report a multicenter Moroccan experience on stereotactic radiotherapy using linear accelerators in the treatment of brain metastases.
Material And Methods: We conducted a multicenter retrospective study that included 130 patients treated at five centers in Morocco for brain metastases during the period between January 2021 and December 2024.
Eur J Cancer
September 2025
Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:
Background: The optimal radiotherapy regimen following mastectomy and immediate breast reconstruction remains under active investigation. In particular, the safety of moderate hypofractionation (HF) compared to conventional fractionation (CF) for postmastectomy radiotherapy (PMRT) has not been clearly established. Given the growing adoption of HF in breast cancer treatment, a thorough synthesis comparing complication outcomes is essential to guide clinical practice.
View Article and Find Full Text PDFCancer Radiother
September 2025
Department of Radiation Oncology, centre de cancérologie des Dentellières, Valenciennes, France. Electronic address:
Radiotherapy, long established as a cornerstone of cancer care, has in recent years broadened its therapeutic reach to include a variety of benign and functional disorders. Advances in imaging, motion management, and highly conformal delivery have made it possible to treat non-malignant conditions with precision and minimal collateral damage. For example, stereotactic arrhythmia radioablation offers a noninvasive, single-session option for refractory ventricular tachycardia, markedly reducing arrhythmic burden and device interventions.
View Article and Find Full Text PDFBull Cancer
August 2025
Service de cancérologie-radiothérapie, hôpital Saint-Louis, Paris, France.
Adjuvant radiotherapy for breast cancer has demonstrated its benefit both in terms of local control and overall survival. However, it now appears possible to de-escalate both the indications and the technical modalities of treatment. Some of these new approaches are already validated, while others require further studies.
View Article and Find Full Text PDF