Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbadis.2025.167802 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differentiation-inducing factor-1 inhibits dendritic cell function by attenuating toll-like receptor 4 and phospho-nuclear factor-κB signaling in vitro.
Int Immunopharmacol
August 2025
Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Dendritic cells (DCs) play a crucial role in initiating immune responses by presenting antigens to naïve T cells. Differentiation-inducing factor (DIF)-1, a signaling molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum, has limited known effects on murine bone marrow-derived DCs. In this study, DIF-1 attenuated both the phenotypic and functional activation of murine DCs upon stimulation with lipopolysaccharide (LPS).
View Article and Find Full Text PDFDifferentiation-inducing factor-1 ameliorates liver fibrosis through the reversion of activated hepatic stellate cells.
Biochim Biophys Acta Mol Basis Dis
June 2025
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka City, Shizuoka 422-8526, Japan.
Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function.
BMC Res Notes
January 2025
Laboratory of Health and Life Science, Graduate School of Health and Sports Science, Juntendo University, Inzai, 270-1695, Japan.
Objective: Dictyostelium differentiation-inducing factors 1 and 3 [DIF-1 (1) and DIF-3 (2), respectively], along with their derivatives, such as Ph-DIF-1 (3) and Bu-DIF-3 (4), demonstrate antibacterial activity in vitro against Gram-positive bacteria, including methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), vancomycin-sensitive Enterococcus faecalis (VSE), and vancomycin-resistant Enterococcus faecium [VRE (VanA)]. This study investigates the therapeutic potential of DIF compounds against these Gram-positive bacteria.
View Article and Find Full Text PDFDifferentiation-inducing factor-1 inhibits EMT by proteasomal degradation of TAZ and YAP in cervical and colon cancer cell lines.
Eur J Pharmacol
January 2025
Department of Pharmacology, Faculty of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan. Electronic address:
We previously reported differentiation-inducing factor-1 (DIF-1) activated glycogen synthase kinase-3 (GSK-3) in various mammalian cells. GSK-3 has been proposed to regulate a number of signaling pathway including TAZ/YAP signaling pathway. To clarify the effect of DIF-1 on TAZ/YAP signaling pathway, we examined whether DIF-1 affect the expression levels of TAZ and YAP.
View Article and Find Full Text PDFResearch on a Minor Organism can also be Benefit the World: The Fascinating Cellular Slime Mold .
Juntendo Iji Zasshi
September 2024
In 1985, when I entered the Graduate School of Science at Kyoto University, I began my research on cellular slime molds, a group of soil microorganisms. The cellular slime mold is studied globally as a model organism for cell and developmental biology. I was conducting basic biological research into cell differentiation and migration using , and during this process, our research group made a discovery with potential implications for drug development.
View Article and Find Full Text PDF