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Article Abstract
Introduction: Short-chain fatty acids (SCFAs) are small molecule metabolites mainly produced during microbial fermentation of dietary fibre in the gut and have been shown to have a beneficial impact on human health. The aim of this study was to evaluate the effect of SCFAs on human skeletal muscle energy metabolism.
Methods: Primary human myotubes were analysed for glucose and fatty acid (oleic acid) metabolism, as well as insulin sensitivity and protein synthesis in the presence or absence of SCFAs.
Results: The most pronounced effects of SCFAs were observed on C-oleic acid uptake and oxidation, as well as C-leucine uptake and protein synthesis, following butyrate treatment. Butyrate increased C-leucine accumulation twofold, potentially due to protein incorporation. On the other hand, the conversion of C-leucine into free fatty acids was reduced by more than 50% by butyrate. Both C-acetate and C-butyrate were shown to be taken up and utilised by primary human myotubes. None of the SCFAs were found to influence glucose metabolism or insulin effects.
Conclusion: The results from the current study thus suggest that among the SCFAs, butyrate emerges as the most powerful SCFA in regulating primary human myotube metabolism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885951 | PMC |
| http://dx.doi.org/10.1002/edm2.70042 | DOI Listing |
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