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Aims: We investigated the effect of continuous glucose monitoring (CGM) with personalised structured education on patients with type 2 diabetes (T2D) and pre-diabetes in a workplace setting.
Materials And Methods: This 8-week prospective study enrolled adults with T2D or pre-diabetes at Samsung Electronics Device Solutions between March and September 2023. Participants underwent CGM (Freestyle Libre) for 2 weeks and received personalized structured education on diet and physical activity. The primary outcome was the change in HbA1c level at 8 weeks compared with baseline. Secondary outcomes included changes in fasting blood sugar (FBS), lipid profile, weight and patient-related outcome measures (PROMs) at 8 weeks and longer.
Results: Among 234 participants (161 T2D and 73 pre-diabetes), significant improvements were observed in the T2D group patients in terms of HbA1c (6.9% ± 1.2%-6.5% ± 0.8%), FBS (128.4 ± 36.9-117.6 ± 22.2 mg/dL), weight (81.9 ± 13.5-80.7 ± 13.6 kg) and low-density lipoprotein (LDL) cholesterol (106.0 ± 41.5 to 95.1 ± 35.9 mg/dL) (all p < 0.001) levels. Meanwhile, patients with pre-diabetes showed significant improvements in weight (79.7 ± 14.0-78.5 ± 13.9 kg) and LDL cholesterol (124.5 ± 32.8-113.8 ± 29.1 mg/dL) (all p < 0.001), with no significant changes in HbA1c or FBS. These improvements were maintained during follow-up check-ups after a mean of 6.4 months. Participants in both groups demonstrated improvements in their PROMs.
Conclusions: Among adults with T2D and pre-diabetes, the use of CGM with structured education in a workplace-based setting helped with weight loss and improved LDL cholesterol levels in both groups, while also improving glycaemia in patients with T2D.
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http://dx.doi.org/10.1111/dom.16304 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug De
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts.
View Article and Find Full Text PDFChaos
September 2025
Indian Institute of Science Education and Research, Tirupati, Andhra Pradesh 517507, India.
Adaptation in complex systems implies a natural ability to change. In networks, adaptation may include a change in structural connectivity, which can lead to a change in collective behavior. When dihedral symmetry is present, i.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
September 2025
Key Laboratory of the Ministry of Education for Wildlife and Plant Resources Conservation in Southwest China, College of Life Sciences, China West Normal University, Nanchong, Sichuan, China.
Enterotoxigenic Escherichia coli (ETEC) is a prevalent intestinal pathogen that significantly impacts both human and animal health. G83, isolated from giant panda feces, has demonstrated notable probiotic properties. In this study, C57BL/6 J mice were randomly divided into Control, ETEC, and G83 groups.
View Article and Find Full Text PDFIn Vitro Cell Dev Biol Anim
September 2025
Postgraduate Program in Physiological Sciences (PPGCF), State University of Ceará (UECE), Fortaleza, CE, Brazil.
The present study aimed to (1) evaluate the effects of different concentrations of the polysaccharide extract of Cissus sicyoides (PE-Cs) during in vitro culture of preantral follicles included in goat ovarian tissue on (i) follicular morphology and activation, (ii) ovarian stromal density, (iii) follicular and oocyte diameters, (iv) antioxidant enzymes activity (SOD, CAT, and GPx), (v) quantification of MDA, thiol, and nitrite levels; as well as to (2) measure the total antioxidant capacity of the extract. The ovarian cortex fragments were cultured at 39 °C in a humidified atmosphere with 5% CO for 6 d in alpha-modified minimum essential medium (αMEM) supplemented with insulin, transferrin, and selenium; hypoxanthine; glutamine; and bovine serum albumin, which was called αMEM alone or added of PE-Cs at 20, 40, or 80 µg/mL. At the end of the culture period, a reduction in the percentage of normal follicles in all treatments using PE-Cs compared to fresh control and αMEM.
View Article and Find Full Text PDFDiscov Nano
September 2025
Department of Rehabilitation Medicine, Rehabilitation Medical Center, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Immunoelectron Microscopy (IEM) is a technique that combines specific immunolabeling with high-resolution electron microscopic imaging to achieve precise spatial localization of biomolecules at the subcellular scale (< 10 nm) by using high-electron-density markers such as colloidal gold and quantum dots. As a core tool for analyzing the distribution of proteins, organelle interactions, and localization of disease pathology markers, it has irreplaceable value, especially in synapse research, pathogen-host interaction mechanism, and tumor microenvironment analysis. According to the differences in labeling sequence and sample processing, the IEM technology system can be divided into two categories: the first is pre-embedding labeling, which optimizes the labeling efficiency through the pre-exposure of antigenic epitopes and is especially suitable for the detection of low-abundance and sensitive antigens; the second is post-embedding labeling, which relies on the low-temperature resin embedding (e.
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