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Difficulties in mastering handwriting affect 10-30% of pupils, with detrimental effects if untreated. Thus, their early detection is of utter importance. Technology can enrich the standard pen-and-paper assessment with quantitative information on the handwriting process, provided it can describe both its development and impairments in childhood. In this work, 530 pupils from 1 to 5 grade performed a subtest from the Italian clinical gold standard for writing fluency assessment. They wrote the sequence of numbers as words, as fast as possible, for one minute in uppercase font. An innovative sensorized ink pen (SIP), able to collect kinematic and dynamic signals while writing on paper, was used for data acquisition. From the data, temporal, fluency, and pressure indicators were computed and subjected to statistical analysis to evaluate handwriting learning curves and sensitivity to difficulties, revealed by the writing fluency test. All domains showed a significant learning effect (p-value < 0.001). A relevant evolution in the handwriting pattern in the first three years emerged, with significant differences between adjacent classes (p-value < 0.001), followed by a plateau. The indicators were also statistically different (p-value < 0.001) between proficient and nonproficient writers. Beginner and nonproficient writers were characterized by reduced speed both with the SIP on paper and in air, jerky movements and scarce modulation of the force exerted on the writing surface. These findings, in line with the existing literature, foster the integration of the SIP in the early screening of handwriting difficulties.
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http://dx.doi.org/10.1109/EMBC53108.2024.10782390 | DOI Listing |
Br J Cancer
September 2025
Department of Genetics, Institut Curie, PSL Research University, Paris, France.
Background: Identifying molecular alterations specific to advanced lung adenocarcinomas could provide insights into tumour progression and dissemination mechanisms.
Method: We analysed tumour samples, either from locoregional lesions or distant metastases, from patients with advanced lung adenocarcinoma from the SAFIR02-Lung trial by targeted sequencing of 45 cancer genes and comparative genomic hybridisation array and compared them to early tumours samples from The Cancer Genome Atlas.
Results: Differences in copy-number alterations frequencies suggest the involvement in tumour progression of LAMB3, TNN/KIAA0040/TNR, KRAS, DAB2, MYC, EPHA3 and VIPR2, and in metastatic dissemination of AREG, ZNF503, PAX8, MMP13, JAM3, and MTURN.
Epidemiol Serv Saude
September 2025
Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Saúde Coletiva Porto Alegre, RS, Brazil.
Objective: To analyze the mental health of Brazilian adolescent mothers who use the Unified Health System (Sistema Único de Saúde, SUS).
Methods: This is a multicenter study conducted with 583 adolescent mothers (10-19 years old). The participants responded to a questionnaire on sociodemographic variables, mental health and family support.
Int J Colorectal Dis
September 2025
Internal Medicine Department, Mirwais Regional Hospital, Kandahar, Afghanistan.
Background: The primary treatment for colorectal cancer, which is very prevalent, is surgery. Anastomotic leaking poses a significant risk following surgery. Intestinal perfusion can be objectively and instantly assessed with indocyanine green fluorescence imaging, which may lower leakage rates and enhance surgical results.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
The population of pensioners remains on the rise in Ghana coupled with an intrinsic need for sexual activity and satisfaction. However, data on factors associated with sexual satisfaction among pensioners are limited in Ghana. The aim of this study was to examine the predictors of sexual satisfaction among Social Security and National Insurance Trust pensioners in the Greater Accra Region of Ghana.
View Article and Find Full Text PDFJ Nephrol
September 2025
Institute of Nephrology, Madras Medical College, Chennai, India.
Background: IgA nephropathy is a disease with a highly variable natural history, for which there is an increasing understanding of the role of complement activation in its pathogenesis and progression. We aimed to assess the clinical and prognostic implications of C4d staining in the kidney biopsy of IgA nephropathy patients.
Methods: This was a retrospective observational study wherein the medical records of IgA nephropathy patients were reviewed and baseline characteristics, kidney biopsy findings, treatment response and follow-up data were noted.