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Article Abstract
In this paper, we present a two-compartmental multiscale mechanistic model for investigating anti-miR-155 monotherapy for non-small cell lung cancer (NSCLC). The model was first quantified using in vivo data and subsequently extrapolated to human-scale for evaluating its translational potential in patients. Using the human-scale model, we explored the impact of dosing schedules on tumor response. The model demonstrated the efficacy of anti-miR-155 monotherapy in a virtual NSCLC patient, revealing treatment schedule-dependent suppression of tumor growth. Further analysis of the model will include testing the synergistic effects of anti-miR-155 with standard-of-care drugs, which will help design and optimize treatment schedules for combination therapy in NSCLC.
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| http://dx.doi.org/10.1109/EMBC53108.2024.10782406 | DOI Listing |
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