Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871783PMC
http://dx.doi.org/10.1186/s12967-025-06272-1DOI Listing

Publication Analysis

Top Keywords

revisiting abcb1
4
abcb1 polymorphism
4
polymorphism missing
4
missing piece
4
piece alzheimer's
4
alzheimer's risk
4
risk treatment?
4
revisiting
1
polymorphism
1
missing
1

Similar Publications

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma.

Pharmaceuticals (Basel)

January 2025

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.

: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters function as drug transporters and have been touted to be the main culprits in developing resistance to xenobiotic drugs in GBM. : This review systematically analyzed the efficacy of ABC transporters against various anticancer drugs from 16 studies identified from five databases (PubMed, Medline, Embase, Scopus, and ScienceDirect).

View Article and Find Full Text PDF

Most patients who die of cancer have disseminated disease that has become resistant to multiple therapeutic modalities. Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (MDR1, also known as P-glycoprotein or P-gp), which is encoded by ABC subfamily B member 1 (ABCB1), can confer resistance to cytotoxic and targeted chemotherapy. However, the development of MDR1 as a therapeutic target has been unsuccessful.

View Article and Find Full Text PDF

Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro. Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available (i.

View Article and Find Full Text PDF

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene.

J Natl Cancer Inst

September 2015

Laboratory of Cell Biology (MMG) and Laboratory of Molecular Biology (IHP), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

View Article and Find Full Text PDF