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http://dx.doi.org/10.1001/jamaoncol.2024.7051 | DOI Listing |
Nat Metab
September 2025
Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Itaconate is an immunomodulatory metabolite that alters mitochondrial metabolism and immune cell function. This organic acid is endogenously synthesized by tricarboxylic acid (TCA) metabolism downstream of TLR signalling. Itaconate-based treatment strategies are under investigation to mitigate numerous inflammatory conditions.
View Article and Find Full Text PDFeNeuro
September 2025
Department of Neurobiology and McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL35294 and.
The plasma membrane acts as a capacitor that plays a critical role in neuronal excitability and signal propagation. Neuronal capacitance is proportional to the area of the cell membrane, thus is often used as a measure of cell size that is assumed to be relatively stable. Recent work proposes that the capacitance of dentate granule cells and cortical pyramidal cells changes across the light-dark cycle in a manner that alters synaptic integration.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Biol Lipids
September 2025
Laboratory of Biochemistry, University of Crete Medical School and Gene Regulation and Genomics group, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion, Crete, Greece. Electronic address:
Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk, partly attributed to altered lipid metabolism. Apolipoprotein C-III (apoC-III), a key regulator of triglyceride-rich lipoproteins in the plasma, has been implicated in both dyslipidemia and inflammation. In this study, we investigated the role of hypertriglyceridemia in RA using a transgenic mouse model overexpressing the human apoC-III gene (apoC-III Tg).
View Article and Find Full Text PDFBiol Psychiatry
September 2025
Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, CA; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Canada; Division of Endocrinology, Children's Hospital LA, Los Angeles, CA; Department of Pediatrics, Keck Scho
Background: Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigations into biological processes that have been perturbed by ELA have profiled DNA methylation in whole blood and coalesced around perturbations of immunobiology being centrally insulted by ELA.
Methods: To identify novel molecular signatures that are enduringly perturbed by childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques that had either experienced nurturing maternal care (CONT, n = 7, 4M 3F) or maltreatment in infancy (MALT, n = 6, 3M 3F).
Fish Shellfish Immunol
September 2025
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Republic of Korea. Electronic address:
Extracellular vesicles (EVs) or their sub types, such as exosomes are valuable nano-biomolecules for immunotherapeutic, drug delivery, and diagnostic purposes. Freshwater and marine fish, including olive flounder (Paralichthys olivaceus), are highly susceptible to the contagious Viral hemorrhagic septicemia virus (VHSV). In this study, we aimed to determine how infection alters the biological responses by analyzing the proteomic profiles of plasma-derived exosomes from phosphate buffered saline (PBS) injected (PBS-Exo) and VHSV challenged (VHSV-Exo) olive flounders at the initial stages infection.
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