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A significant challenge that hinders advancements in medical research is the sensitive and confidential nature of patient data in available datasets. In particular, sharing patients' facial images poses considerable privacy risks, especially with the rise of generative artificial intelligence (AI), which could misuse such data if accessed by unauthorized parties. However, facial expressions are a valuable source of information for doctors and researchers, which creates a need for methods to derive them without compromising patient privacy or safety by exposing identifiable facial images. To address this, we present a quick, computationally efficient method for detecting action units (AUs) and their intensities-key indicators of health and emotion-using only 3D facial landmarks. Our proposed framework extracts 3D face landmarks from video recordings and employs a lightweight neural network (NN) to identify AUs and estimate AU intensities based on these landmarks. Our proposed method reaches a 79.25% F1-score in AU detection for the main AUs, and 0.66 in AU intensity estimation Root Mean Square Error (RMSE). This performance shows that it is possible for researchers to share 3D landmarks, which are far less intrusive, instead of facial images while maintaining high accuracy in AU detection. Moreover, to showcase the usefulness of our AU detection model, using the detected AUs and estimated intensities, we trained state-of-the-art Deep Learning (DL) models to detect pain. Our method reaches 91.16% accuracy in pain detection, which is not far behind the 93.14% accuracy obtained when employing a convolutional neural network (CNN) with residual blocks trained on actual images and the 92.11% accuracy obtained when employing all the ground-truth AUs.
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http://dx.doi.org/10.3390/bioengineering12020195 | DOI Listing |
Eur J Case Rep Intern Med
July 2025
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening hematologic emergency caused by ADAMTS13 deficiency, leading to microvascular thrombosis, haemolytic anaemia, thrombocytopenia, and end-organ damage. Neurological symptoms occur in up to 90% of cases and are frequently misdiagnosed as stroke. Prompt recognition and treatment reduce the mortality rate from over 90% to 10-20%.
View Article and Find Full Text PDFCureus
August 2025
Department of Neurosurgery, The University of Osaka Graduate School of Medicine, Suita, JPN.
Fungal cerebral aneurysms, particularly those resulting from direct invasion by fungal sinusitis, are rare and often fatal when involving the cavernous segment of the internal carotid artery (ICA). We present a case of a ruptured fungal ICA aneurysm caused by sinusitis, successfully treated with parent artery occlusion (PAO). In this case, an 80-year-old woman presented with right ptosis, facial pain, and cranial nerve III, IV, and VI palsies.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Neurology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by abnormal megakaryocyte proliferation and a markedly elevated platelet count, which predisposes patients to thrombotic or hemorrhagic events. Approximately 50%-60% of ET patients harbor a JAK2 V617F mutation. This mutation drives constitutive JAK kinase activation, promoting megakaryocyte proliferation and platelet production, while potentially activating inflammatory pathways and damaging vascular endothelium.
View Article and Find Full Text PDFExp Clin Transplant
August 2025
>From the Department of Gastroenterology, Dokuz Eylul University Hospital, Izmir, Türkiye.
Objectives: Liver transplant has significantly improved the survival of patients with end-stage liver disease, yet long-term transplant recipients often face challenges related to graft function and well-being. We aimed to evaluate the clinical role of vibration-controlled transi-ent elastography for assessment of liver fibrosis and steatosis, with a focus on fibrosis and steatosis, in liver transplant recipients who were over 10 years posttrans-plant. In addition, we aimed to identify factors that influence liver function and quality of life in these patients.
View Article and Find Full Text PDFComput Biol Med
September 2025
Postgraduate Program in Computing, Center for Technological Development, Federal University of Pelotas, Pelotas, 96010-610, Rio Grande do Sul, Brazil.
In the task of image classification for emotion recognition, facial expression data is commonly used. However, electrical brain signals generated by neural activity provide data with greater integrity. We can capture these signals non-invasively using electroencephalogram (EEG) recording devices.
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