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Purpose Of Review: Alcohol problem recognition reflects the extent to which a person with any level of problematic alcohol use (PAU), including hazardous alcohol use, acknowledges the associated risks/harms as potentially/actually problematic with a relative degree of objectivity. Notably, alcohol problem recognition is typically low amongst people with PAU not engaged in treatment or support. This review evaluates existing PAU problem recognition measures and related concepts such as ambivalence, readiness to change, motivation, cognitive biases and other self-evaluative appraisal processes.
Recent Findings: Alcohol problem recognition has been operationalised via various measures but is often conflated with other related but theoretically distinct concepts. Limited conceptual work examines the nature of problem recognition as a discrete concept and its function in relation to behaviour change outcomes and key variables.
Summary: Problem recognition is proposed as an important theoretically distinct process that warrants further conceptual development and testing for advancing understanding of change processes across the PAU spectrum.
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http://dx.doi.org/10.1007/s40429-025-00634-x | DOI Listing |
J Chem Inf Model
September 2025
School of Medicine and Warshel Institute for Computational Biology, The Chinese University of Hong Kong─Shenzhen, Shenzhen, Guangdong 518172, China.
Argonaute (Ago) is a DNA-guided programmable endonuclease with emerging applications in genome engineering, yet the rate-determining dynamic mechanisms governing its transition from guide-target hybridization to catalytic activation remain unresolved. Here, we employ molecular dynamics simulations and the Traveling-salesman-based Automated Path Searching (TAPS) approach to dissect the target DNA recognition in the middle region (nt 9-12) of Ago. We designed two paths to tackle this problem: one assumed that coordination of the target DNA backbone occurs before base-pairing between the target and guide DNA; the other hypothesized a concerted transition without preferred order between backbone-coordination and base-pairing.
View Article and Find Full Text PDFEnviron Epidemiol
October 2025
Department of Psychiatry and Behavioral Health, The Ohio State University, Ohio.
Background: Prospective studies suggest that prenatal exposure to chemical neurotoxicants and maternal stress increase risk for psychiatric problems. However, most studies have focused on childhood outcomes, leaving adolescence-a critical period for the emergence or worsening of psychiatric symptoms-relatively understudied. The complexity of prenatal coexposures and adolescent psychiatric comorbidities, particularly among structurally marginalized populations with high exposure burdens, remains poorly understood.
View Article and Find Full Text PDFChem Sci
August 2025
Engineering Research Center of Cell & Therapeutic Antibody (MOE), School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240 China
Predicting Antibody-Antigen (Ab-Ag) docking and structure-based design represent significant long-term and therapeutically important challenges in computational biology. We present SAGERank, a general, configurable deep learning framework for antibody design using Graph Sample and Aggregate Networks. SAGERank successfully predicted the majority of epitopes in a cancer target dataset.
View Article and Find Full Text PDFRheumatology (Oxford)
September 2025
Department of Rheumatology & Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Objectives: Many patients with systemic sclerosis (SSc) experience impaired hand function, yet the precise nature and impact of this impairment remains unclear. In this study, we explored the determinants of hand function impairment in SSc from a patient perspective and its impact on daily life. Additionally, we identified unmet care needs related to hand function impairment.
View Article and Find Full Text PDFPsychother Psychosom Med Psychol
September 2025
Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig.
Since 2020, cancer counselling centers (CCCs) have been eligible for funding from health insurance funds under the legal regulation on "Outpatient Cancer Counseling" (§65e SGB V). This article investigates the rationale for or against applying for funding and evaluates the funding option from the perspective of staff members at both funded and non-funded CCCs, as well as sponsoring organizations. The aim is to analyse the practical feasibility of the financing model.
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