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Article Abstract
The Sonogashira cross-coupling of 2-bromo-3,3-difluoroallyl benzyl sulfide with various terminal acetylenes afforded the corresponding 2-(difluoromethylene)but-3-yn-1-yl benzyl sulfides in acceptable to good yields. Subsequent double iodation of the enyne sulfides in a mixed solvent (CHCl/EtOH = 50/1) provided promising 4-(difluoroiodomethyl)-3-iodo-2-substituted thiophenes in good to excellent yields.
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