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Introduction: Studies have shown that patients with rheumatoid arthritis (RA) have lower levels of physical activity (PA) than healthy controls, despite the benefits of PA in reducing pain and stiffness. We aimed to compare the levels of PA in patients with RA with that of the general population and identify factors associated with meeting the World Health Organization (WHO) recommendations for PA.
Methods: Consecutive patients with RA were recruited from an outpatient rheumatology clinic in a tertiary hospital in Singapore. Data for the general population were obtained from the Singapore Health 2012 study. To obtain comparable controls from the general population, we performed propensity score matching based on age and gender.
Results: Sixty patients with RA were recruited. The proportions of patients with RA and controls who met WHO recommendations for PA were similar (78.3% vs. 80.0%, P = 0.82). After propensity matching, patients with RA spent significantly less time on work-related PA compared to controls (54.3 ± 147.4 min vs. 73.0 ± 132.6 min, P < 0.01). Disease activity was insignificant in determining whether WHO recommendations for PA were met in patients with RA. In the multivariable logistic regression, being employed (odds ratio 4.72, 95% confidence interval 1.20-18.59) was associated with meeting WHO recommendations.
Conclusions: In this study, the proportion of patients with RA who met the recommendations for PA was similar to that of controls after propensity score matching. Among patients with RA, being employed was associated with meeting WHO recommendations for PA.
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http://dx.doi.org/10.4103/singaporemedj.SMJ-2023-167 | DOI Listing |
J Eval Clin Pract
September 2025
Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan.
Background: Chest radiography is often performed preoperatively as a common diagnostic tool. However, chest radiography carries the risk of radiation exposure. Given the uncertainty surrounding the utility of preoperative chest radiographs, physicians require systematically developed recommendations.
View Article and Find Full Text PDFGenet Med
September 2025
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK. Electronic address:
Purpose: Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare cancer susceptibility syndrome exclusively attributable to pathogenic variants in FH (HGNC:3700). This paper quantitatively weights the phenotypic context (PP4/PS4) of such very rare variants in FH.
Methods: We collated clinical diagnostic testing data on germline FH variants from 387 individuals with HLRCC and 1,780 individuals with renal cancer, and compared the frequency of 'very rare' variants in each phenotypic cohort against 562,295 population controls.
Genet Med
September 2025
Division of Medical Genetics, University of Washington School of Medicine.
Purpose: The fourth phase of the Electronic Medical Records and Genome Network (eMERGE4) is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS.
Methods: Fifteen health-system leaders and 20 primary care providers (PCPs) took part in semi-structured interviews.
BJOG
September 2025
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Objective: To compare maternal and neonatal adverse outcomes between women who are English proficient (EP) and those who have limited English proficiency (LEP).
Design: Retrospective cohort study.
Setting: Single US academic medical centre with interpreter services.