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Aortic aneurysms pose a significant risk of rupture. Previous research has shown that areas exposed to low wall shear stress (WSS) are more prone to rupture. Therefore, precise WSS determination on the aneurysm is crucial for rupture risk assessment. Computational fluid dynamics (CFD) is a powerful approach for WSS calculations, but they are computationally intensive, hindering time-sensitive clinical decision-making. In this study, we propose a deep learning (DL) surrogate, MultiViewUNet, to rapidly predict time-averaged WSS (TAWSS) distributions on abdominal aortic aneurysms (AAA). Our novel approach employs a domain transformation technique to translate complex aortic geometries into representations compatible with state-of-the-art neural networks. MultiViewUNet was trained on real and synthetic AAA geometries, demonstrating an average normalized mean absolute error (NMAE) of just in WSS prediction. This framework has the potential to streamline hemodynamic analysis in AAA and other clinical scenarios where fast and accurate stress quantification is essential.
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http://dx.doi.org/10.1007/s11517-025-03311-3 | DOI Listing |
Eur J Vasc Endovasc Surg
September 2025
Department of Vascular Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Cell Rep Med
September 2025
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250012, China; Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong U
Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective treatment. We investigate the role of the deubiquitinating enzyme USP21 in AAA development. Proteomic analysis reveals significant upregulation of USP21 in murine and human abdominal aortic tissues.
View Article and Find Full Text PDFAten Primaria
September 2025
Gerencia de Atención Primaria de Gran Canaria, Las Palmas de Gran Canaria, España.
Aim: To describe the percentage of abdominal aortic aneurysm (AAA) cases in the Maspalomas Basic Health Zone among males aged 65 to 75 years who are current or former smokers. Our secondary objectives were to define the distribution of known risk factors for AAA development in our sample and to facilitate early referral to the appropriate vascular surgery service. We also aim to describe the percentage of subaneurysm cases, offering ultrasound follow-up at our center.
View Article and Find Full Text PDFAten Primaria
September 2025
Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, España.
Objective: To assess the feasibility of implementing ultrasound screening for abdominal aortic aneurysm (AAA) in primary care by examining the prevalence of AAA and associated risk factors in northern Lleida, where no prior data exist and cases are detected opportunistically.
Design: Cross-sectional retrospective prevalence study derived from a pilot implementation of ultrasound AAA screening as a routine complementary test in six rural primary care centres over a 12-month period (March 2022 - March 2023).
Setting: Northern area of the province of Lleida, specifically the regions of Alt Urgell, Pallars Sobirà, Pallars Jussà and Alta Ribagorça.
JTCVS Open
August 2025
Department of Cardiac Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Background: Regular imaging surveillance is guideline-recommended for the management of thoracic aortic aneurysm (TAA) but has not been well described in clinical practice. Here we evaluated the frequency of imaging procedures and associated outcomes, procedures, and healthcare costs in patients with TAA.
Methods: A retrospective cohort study of inpatient and professional claims for 28,459 Medicare beneficiaries age ≥65 years with a diagnosis of TAA between 2017 and 2019 was performed.