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Background: Patients requiring cholecystectomy or appendectomy may present with concomitant COVID infection in both the inpatient and outpatient scenarios. It is unclear whether these patients benefit more from operative or nonoperative management in the setting of active COVID infection. These guidelines seek to address urgent and elective clinical scenarios.
Methods: A systematic review was conducted to address these questions. These results were then presented to an interdisciplinary panel that formulated recommendations based on the best available evidence or utilized expert opinion when the evidence base was lacking.
Results: Conditional recommendations were made in favor of (1) either operative or nonoperative management of COVID-positive patients with appendicitis or cholecystitis and (2) delaying operations by more than six weeks in patients who test positive for COVID in the elective setting.
Conclusions: These recommendations should provide guidance regarding the management of surgical patients with concomitant COVID infection. This guideline also identifies important areas where future research should focus to strengthen the evidence base.
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http://dx.doi.org/10.1007/s00464-025-11526-6 | DOI Listing |
Int J Environ Health Res
September 2025
Department of Research, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Veracruz, Mexico.
Little is known about the biomarkers of mortality in SARS-CoV-2-infected patients without a previous diagnosis of diabetes. Thus, this study aimed to assess the fibrinogen-to-platelet ratio (FPR) and compare its predictive value with the main biomarkers for COVID-19 mortality, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), leukocyte glucose index (LGI), and lactate dehydrogenase (LDH)/lymphocyte ratio. This retrospective cohort study in a population of Mexico included 70 non-diabetic patients with COVID-19 from 1 May 2020 to 30 September 2020.
View Article and Find Full Text PDFClin Exp Immunol
September 2025
Clinical Immunology Service, Institute of Immunology and Immunotherapy, University of Birmingham, B15 2TT.
Since its discovery in the late 18th Century, the role of vaccination in preventing death and disease has expanded across many infectious diseases and cancer. Key to our understanding of vaccine immunogenicity and efficacy is knowledge of the immune system itself. Inborn Errors of Immunity (IEI) represent a heterogeneous group of disorders characterised by impaired function of the immune system.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, Canada.
Young adults in their 20s have shown slower uptake of COVID-19 vaccines relative to older adults, potentially endangering themselves and their communities. Despite this, little vaccine communication has specifically targeted this age group. This study explored why "20-somethings" in British Columbia (BC), Canada delayed COVID-19 vaccination, and how to better encourage their vaccine uptake.
View Article and Find Full Text PDFThe COVID-19 pandemic required healthcare organizations to rapidly upskill workers to care for critically ill patients. An integrative review focused on the upskilling of nurses during the pandemic identified themes of strategies, benefits, and challenges of rapid upskilling. Understanding the effectiveness, satisfaction, and challenges of upskilling efforts during COVID-19 can help healthcare organizations prepare for future emergencies by improving workforce readiness and response strategies.
View Article and Find Full Text PDFReprod Health
September 2025
Department of Sexual and Reproductive Health including UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Avenue Appia 20, 1211, Geneva, Switzerland.
Background: The COVID-19 pandemic disrupted the provision of sexual and reproductive health services, including contraceptive and family planning (FP) services. The World Health Organization conducted a multi-country study in India, Nigeria and Tanzania to assess the impact of the pandemic on the health system's capacity to provide contraceptive and FP services. In this paper, we share the results of a qualitative study aimed at understanding clients' perspectives at the primary healthcare level on accessing contraceptive services in COVID-19-affected areas in the three aforementioned countries.
View Article and Find Full Text PDF